Free Radical Scavenging Activities Measured by Electron Spin Resonance Spectroscopy and B16 Cell Antiproliferative Behaviors of Seven Plants
In an effort to discover new antioxidant natural compounds, seven plants that grow in France (most of them in the Limousin countryside) were screened. Among these plants, was the extensively studied Vitis vinifera as reference. For each plant, sequential percolation was realized with five solvents o...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2001-07, Vol.49 (7), p.3321-3327 |
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| creator | Calliste, Claude-Alain Trouillas, Patrick Allais, Daovy-Paulette Simon, Alain Duroux, Jean-Luc |
| description | In an effort to discover new antioxidant natural compounds, seven plants that grow in France (most of them in the Limousin countryside) were screened. Among these plants, was the extensively studied Vitis vinifera as reference. For each plant, sequential percolation was realized with five solvents of increasing polarities (hexane, chloroform, ethyl acetate, methanol, and water). Free radical scavenging activities were examined in different systems using electron spin resonance (ESR) spectroscopy. These assays were based on the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), the hydroxyl radicals generated by a Fenton reaction, and the superoxide radicals generated by the X/XO system. Antiproliferative behavior was studied on B16 melanoma cells. ESR results showed that three plants (Castanea sativa, Filipendula ulmaria, and Betula pendula) possessed, for the most polar fractions (presence of phenolic compounds), high antioxidant activities in comparison with the Vitis vinifera reference. Gentiana lutea was the only one that presented a hydroxyl scavenging activity for the ethyl acetate and chloroform fractions. The antiproliferative test results showed that the same three plants are the most effective, but for the apolar fractions (chloroform and hexane). Keywords: Radical scavenging; plant extracts; B16 cells; phenolic compounds; ESR |
| doi_str_mv | 10.1021/jf010086v |
| format | Article |
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Among these plants, was the extensively studied Vitis vinifera as reference. For each plant, sequential percolation was realized with five solvents of increasing polarities (hexane, chloroform, ethyl acetate, methanol, and water). Free radical scavenging activities were examined in different systems using electron spin resonance (ESR) spectroscopy. These assays were based on the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), the hydroxyl radicals generated by a Fenton reaction, and the superoxide radicals generated by the X/XO system. Antiproliferative behavior was studied on B16 melanoma cells. ESR results showed that three plants (Castanea sativa, Filipendula ulmaria, and Betula pendula) possessed, for the most polar fractions (presence of phenolic compounds), high antioxidant activities in comparison with the Vitis vinifera reference. Gentiana lutea was the only one that presented a hydroxyl scavenging activity for the ethyl acetate and chloroform fractions. The antiproliferative test results showed that the same three plants are the most effective, but for the apolar fractions (chloroform and hexane). Keywords: Radical scavenging; plant extracts; B16 cells; phenolic compounds; ESR</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf010086v</identifier><identifier>PMID: 11453770</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Antioxidants - analysis ; Antioxidants - metabolism ; Biological and medical sciences ; Electron Spin Resonance Spectroscopy - methods ; Free Radical Scavengers - analysis ; Free Radical Scavengers - metabolism ; General pharmacology ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Reactive Oxygen Species</subject><ispartof>Journal of agricultural and food chemistry, 2001-07, Vol.49 (7), p.3321-3327</ispartof><rights>Copyright © 2001 American Chemical Society</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a444t-1f28fc9e2ea89b031d25a1a4dace9a74b95632fcc8c7b20196877994ac294bb73</citedby><cites>FETCH-LOGICAL-a444t-1f28fc9e2ea89b031d25a1a4dace9a74b95632fcc8c7b20196877994ac294bb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf010086v$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf010086v$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1071545$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11453770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calliste, Claude-Alain</creatorcontrib><creatorcontrib>Trouillas, Patrick</creatorcontrib><creatorcontrib>Allais, Daovy-Paulette</creatorcontrib><creatorcontrib>Simon, Alain</creatorcontrib><creatorcontrib>Duroux, Jean-Luc</creatorcontrib><title>Free Radical Scavenging Activities Measured by Electron Spin Resonance Spectroscopy and B16 Cell Antiproliferative Behaviors of Seven Plants</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>In an effort to discover new antioxidant natural compounds, seven plants that grow in France (most of them in the Limousin countryside) were screened. Among these plants, was the extensively studied Vitis vinifera as reference. For each plant, sequential percolation was realized with five solvents of increasing polarities (hexane, chloroform, ethyl acetate, methanol, and water). Free radical scavenging activities were examined in different systems using electron spin resonance (ESR) spectroscopy. These assays were based on the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), the hydroxyl radicals generated by a Fenton reaction, and the superoxide radicals generated by the X/XO system. Antiproliferative behavior was studied on B16 melanoma cells. ESR results showed that three plants (Castanea sativa, Filipendula ulmaria, and Betula pendula) possessed, for the most polar fractions (presence of phenolic compounds), high antioxidant activities in comparison with the Vitis vinifera reference. Gentiana lutea was the only one that presented a hydroxyl scavenging activity for the ethyl acetate and chloroform fractions. The antiproliferative test results showed that the same three plants are the most effective, but for the apolar fractions (chloroform and hexane). Keywords: Radical scavenging; plant extracts; B16 cells; phenolic compounds; ESR</description><subject>Antioxidants - analysis</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Electron Spin Resonance Spectroscopy - methods</subject><subject>Free Radical Scavengers - analysis</subject><subject>Free Radical Scavengers - metabolism</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Reactive Oxygen Species</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkNFu0zAUhi0EYqVwwQsgXzCkXQRsJ47jy7baGNqA0Q5urRPnZLikTrGTir4DD42h1eCCK8s-n37_5yPkOWevORP8zbplnLGq3D0gEy4FyyTn1UMyYWmYVbLkJ-RJjGuWGKnYY3LCeSFzpdiE_LwIiHQJjbPQ0ZWFHfo75-_ozA5u5waHkb5HiGPAhtZ7et6hHULv6WrrPF1i7D14i-n65z3afrun4Bs65yVdYNfRmR_cNvSdazFAykQ6x6-wc32ItG_pCtOP9KYDP8Sn5FELXcRnx3NKPl-c3y4us-uPb98tZtcZFEUxZLwVVWs1CoRK1yznjZDAoWjAogZV1FqWuWitrayqBeO6rJTSugArdFHXKp-SV4fc1Ov7iHEwGxdtKgse-zEalawWQusEnh1Am1aLAVuzDW4DYW84M7_Vm3v1iX1xDB3rDTZ_yaPrBLw8AhCT7DYkcS7-k6i4TOiUZAfMxQF_3I8hfDOlypU0tzcrc7W8-rBYfpqbL4k_PfBgo1n3Y_BJ3X_6_QJMH6ga</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Calliste, Claude-Alain</creator><creator>Trouillas, Patrick</creator><creator>Allais, Daovy-Paulette</creator><creator>Simon, Alain</creator><creator>Duroux, Jean-Luc</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Free Radical Scavenging Activities Measured by Electron Spin Resonance Spectroscopy and B16 Cell Antiproliferative Behaviors of Seven Plants</title><author>Calliste, Claude-Alain ; Trouillas, Patrick ; Allais, Daovy-Paulette ; Simon, Alain ; Duroux, Jean-Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a444t-1f28fc9e2ea89b031d25a1a4dace9a74b95632fcc8c7b20196877994ac294bb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antioxidants - analysis</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>Electron Spin Resonance Spectroscopy - methods</topic><topic>Free Radical Scavengers - analysis</topic><topic>Free Radical Scavengers - metabolism</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Reactive Oxygen Species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calliste, Claude-Alain</creatorcontrib><creatorcontrib>Trouillas, Patrick</creatorcontrib><creatorcontrib>Allais, Daovy-Paulette</creatorcontrib><creatorcontrib>Simon, Alain</creatorcontrib><creatorcontrib>Duroux, Jean-Luc</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calliste, Claude-Alain</au><au>Trouillas, Patrick</au><au>Allais, Daovy-Paulette</au><au>Simon, Alain</au><au>Duroux, Jean-Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free Radical Scavenging Activities Measured by Electron Spin Resonance Spectroscopy and B16 Cell Antiproliferative Behaviors of Seven Plants</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>49</volume><issue>7</issue><spage>3321</spage><epage>3327</epage><pages>3321-3327</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>In an effort to discover new antioxidant natural compounds, seven plants that grow in France (most of them in the Limousin countryside) were screened. Among these plants, was the extensively studied Vitis vinifera as reference. For each plant, sequential percolation was realized with five solvents of increasing polarities (hexane, chloroform, ethyl acetate, methanol, and water). Free radical scavenging activities were examined in different systems using electron spin resonance (ESR) spectroscopy. These assays were based on the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), the hydroxyl radicals generated by a Fenton reaction, and the superoxide radicals generated by the X/XO system. Antiproliferative behavior was studied on B16 melanoma cells. ESR results showed that three plants (Castanea sativa, Filipendula ulmaria, and Betula pendula) possessed, for the most polar fractions (presence of phenolic compounds), high antioxidant activities in comparison with the Vitis vinifera reference. Gentiana lutea was the only one that presented a hydroxyl scavenging activity for the ethyl acetate and chloroform fractions. The antiproliferative test results showed that the same three plants are the most effective, but for the apolar fractions (chloroform and hexane). Keywords: Radical scavenging; plant extracts; B16 cells; phenolic compounds; ESR</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>11453770</pmid><doi>10.1021/jf010086v</doi><tpages>7</tpages></addata></record> |
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| subjects | Antioxidants - analysis Antioxidants - metabolism Biological and medical sciences Electron Spin Resonance Spectroscopy - methods Free Radical Scavengers - analysis Free Radical Scavengers - metabolism General pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Reactive Oxygen Species |
| title | Free Radical Scavenging Activities Measured by Electron Spin Resonance Spectroscopy and B16 Cell Antiproliferative Behaviors of Seven Plants |
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