Measurement of ataxic symptoms with a graphic tablet: standard values in controls and validity in Multiple Sclerosis patients
Aim of our study was to find a specific measure for the intensity of upper limb tremor and other ataxic symptoms in Multiple Sclerosis (MS) patients, and to establish standard values and test quality parameters. Three hundred and forty-two consecutive patients with different symptoms in the upper li...
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| Veröffentlicht in: | Journal of neuroscience methods 2001-07, Vol.108 (1), p.25-37 |
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| creator | Erasmus, Lutz-Peter Sarno, Stefania Albrecht, Holger Schwecht, Martina Pöllmann, Walter König, Nicolaus |
| description | Aim of our study was to find a specific measure for the intensity of upper limb tremor and other ataxic symptoms in Multiple Sclerosis (MS) patients, and to establish standard values and test quality parameters. Three hundred and forty-two consecutive patients with different symptoms in the upper limbs (upper motor neuron symptoms, cerebellar upper limb ataxia, and/or sensory deficits in the upper limbs) and 140 healthy controls took part in the study. All patients and controls had to trace over a 25 cm high figure ‘8’ on a graphic tablet, to tap with the stylus on the tablet and to perform the nine-hole-peg test (9HPT). Patients were additionally examined using clinical standard scales to classify motor dysfunctions of the upper limbs. One hundred and eighty-nine patients and 27 controls were tested twice to investigate the test reliability. Kinematic analysis of the tablet data was performed by kernel estimators, oscillatory activity by spectral analysis. Total power in the 2–10 Hz band was very specific for ataxia versus other motor symptoms. Tapping and 9HPT could well distinguish patients from controls, and patients with predominant motor neuron or cerebellar symptoms from patients with predominant sensory dysfunctions. Mean drawing error did not differ between motor and sensory dysfunctions. The test–retest reliability was similarly high for both spectral analysis and 9HPT. |
| doi_str_mv | 10.1016/S0165-0270(01)00373-9 |
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Three hundred and forty-two consecutive patients with different symptoms in the upper limbs (upper motor neuron symptoms, cerebellar upper limb ataxia, and/or sensory deficits in the upper limbs) and 140 healthy controls took part in the study. All patients and controls had to trace over a 25 cm high figure ‘8’ on a graphic tablet, to tap with the stylus on the tablet and to perform the nine-hole-peg test (9HPT). Patients were additionally examined using clinical standard scales to classify motor dysfunctions of the upper limbs. One hundred and eighty-nine patients and 27 controls were tested twice to investigate the test reliability. Kinematic analysis of the tablet data was performed by kernel estimators, oscillatory activity by spectral analysis. Total power in the 2–10 Hz band was very specific for ataxia versus other motor symptoms. Tapping and 9HPT could well distinguish patients from controls, and patients with predominant motor neuron or cerebellar symptoms from patients with predominant sensory dysfunctions. Mean drawing error did not differ between motor and sensory dysfunctions. The test–retest reliability was similarly high for both spectral analysis and 9HPT.</description><identifier>ISSN: 0165-0270</identifier><identifier>EISSN: 1872-678X</identifier><identifier>DOI: 10.1016/S0165-0270(01)00373-9</identifier><identifier>PMID: 11459615</identifier><identifier>CODEN: JNMEDT</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Arm - innervation ; Arm - physiopathology ; Ataxia - diagnosis ; Ataxia - etiology ; Ataxia - physiopathology ; Biological and medical sciences ; Biomechanical Phenomena ; Cerebellar tremor ; Computer Graphics - instrumentation ; Diagnosis, Computer-Assisted - instrumentation ; Diagnosis, Computer-Assisted - methods ; Disability Evaluation ; Female ; Graphic tablet ; Handwriting ; Humans ; Kinematic analysis ; Limb ataxia ; Male ; Medical sciences ; Middle Aged ; Multiple Sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Muscle Spasticity - diagnosis ; Muscle Spasticity - etiology ; Muscle Spasticity - physiopathology ; Neurologic Examination - instrumentation ; Neurologic Examination - methods ; Neurologic Examination - standards ; Neurology ; Neuropsychological Tests ; Psychomotor Performance - physiology ; Reference Values ; Reproducibility of Results ; Sex Factors ; Spectral analysis ; Tremor - diagnosis ; Tremor - etiology ; Tremor - physiopathology ; User-Computer Interface</subject><ispartof>Journal of neuroscience methods, 2001-07, Vol.108 (1), p.25-37</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-bddf608f47f11feec046a637702f6755506d6c8f613ad80ea88a8c88fa65b7c83</citedby><cites>FETCH-LOGICAL-c391t-bddf608f47f11feec046a637702f6755506d6c8f613ad80ea88a8c88fa65b7c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165027001003739$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14128719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11459615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erasmus, Lutz-Peter</creatorcontrib><creatorcontrib>Sarno, Stefania</creatorcontrib><creatorcontrib>Albrecht, Holger</creatorcontrib><creatorcontrib>Schwecht, Martina</creatorcontrib><creatorcontrib>Pöllmann, Walter</creatorcontrib><creatorcontrib>König, Nicolaus</creatorcontrib><title>Measurement of ataxic symptoms with a graphic tablet: standard values in controls and validity in Multiple Sclerosis patients</title><title>Journal of neuroscience methods</title><addtitle>J Neurosci Methods</addtitle><description>Aim of our study was to find a specific measure for the intensity of upper limb tremor and other ataxic symptoms in Multiple Sclerosis (MS) patients, and to establish standard values and test quality parameters. Three hundred and forty-two consecutive patients with different symptoms in the upper limbs (upper motor neuron symptoms, cerebellar upper limb ataxia, and/or sensory deficits in the upper limbs) and 140 healthy controls took part in the study. All patients and controls had to trace over a 25 cm high figure ‘8’ on a graphic tablet, to tap with the stylus on the tablet and to perform the nine-hole-peg test (9HPT). Patients were additionally examined using clinical standard scales to classify motor dysfunctions of the upper limbs. One hundred and eighty-nine patients and 27 controls were tested twice to investigate the test reliability. Kinematic analysis of the tablet data was performed by kernel estimators, oscillatory activity by spectral analysis. Total power in the 2–10 Hz band was very specific for ataxia versus other motor symptoms. Tapping and 9HPT could well distinguish patients from controls, and patients with predominant motor neuron or cerebellar symptoms from patients with predominant sensory dysfunctions. Mean drawing error did not differ between motor and sensory dysfunctions. The test–retest reliability was similarly high for both spectral analysis and 9HPT.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Arm - innervation</subject><subject>Arm - physiopathology</subject><subject>Ataxia - diagnosis</subject><subject>Ataxia - etiology</subject><subject>Ataxia - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Cerebellar tremor</subject><subject>Computer Graphics - instrumentation</subject><subject>Diagnosis, Computer-Assisted - instrumentation</subject><subject>Diagnosis, Computer-Assisted - methods</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Graphic tablet</subject><subject>Handwriting</subject><subject>Humans</subject><subject>Kinematic analysis</subject><subject>Limb ataxia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Muscle Spasticity - diagnosis</subject><subject>Muscle Spasticity - etiology</subject><subject>Muscle Spasticity - physiopathology</subject><subject>Neurologic Examination - instrumentation</subject><subject>Neurologic Examination - methods</subject><subject>Neurologic Examination - standards</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Psychomotor Performance - physiology</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Sex Factors</subject><subject>Spectral analysis</subject><subject>Tremor - diagnosis</subject><subject>Tremor - etiology</subject><subject>Tremor - physiopathology</subject><subject>User-Computer Interface</subject><issn>0165-0270</issn><issn>1872-678X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtuFDEQRS1ERIbAJ4C8IYJFg90P280mQhGPSIlYBCR2Vo1dJkbuB7Y7MAv-HXdmRJZsbKnqVNXVIeQZZ6854-LNdXm6itWSvWT8FWONbKr-AdlwJetKSPXtIdn8Q47J45R-MMbanolH5JjztusF7zbkzxVCWiIOOGY6OQoZfntD026Y8zQk-svnGwr0e4T5ptQzbAPmtzRlGC1ES28hLJioH6mZxhynkGjprGVvfd6tjaslZD8HpNcmYJyST3SG7MvB9IQcOQgJnx7-E_L1w_sv55-qy88fL87fXVam6XmuttY6wZRrpePcIRrWChCNlKx2QnZdx4QVRjnBG7CKISgFyijlQHRbaVRzQk73e-c4_Sx5sx58MhgCjDgtSUvO6qZTK9jtQVOCpohOz9EPEHeaM71613fe9SpVM67vvOu-zD0_HFi2A9r7qYPoArw4AJAMBBdhND7dcy2vleTrorM9h0XHrceokymqDFof0WRtJ_-fKH8BShShxg</recordid><startdate>20010715</startdate><enddate>20010715</enddate><creator>Erasmus, Lutz-Peter</creator><creator>Sarno, Stefania</creator><creator>Albrecht, Holger</creator><creator>Schwecht, Martina</creator><creator>Pöllmann, Walter</creator><creator>König, Nicolaus</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010715</creationdate><title>Measurement of ataxic symptoms with a graphic tablet: standard values in controls and validity in Multiple Sclerosis patients</title><author>Erasmus, Lutz-Peter ; Sarno, Stefania ; Albrecht, Holger ; Schwecht, Martina ; Pöllmann, Walter ; König, Nicolaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-bddf608f47f11feec046a637702f6755506d6c8f613ad80ea88a8c88fa65b7c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Arm - innervation</topic><topic>Arm - physiopathology</topic><topic>Ataxia - diagnosis</topic><topic>Ataxia - etiology</topic><topic>Ataxia - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Cerebellar tremor</topic><topic>Computer Graphics - instrumentation</topic><topic>Diagnosis, Computer-Assisted - instrumentation</topic><topic>Diagnosis, Computer-Assisted - methods</topic><topic>Disability Evaluation</topic><topic>Female</topic><topic>Graphic tablet</topic><topic>Handwriting</topic><topic>Humans</topic><topic>Kinematic analysis</topic><topic>Limb ataxia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Muscle Spasticity - diagnosis</topic><topic>Muscle Spasticity - etiology</topic><topic>Muscle Spasticity - physiopathology</topic><topic>Neurologic Examination - instrumentation</topic><topic>Neurologic Examination - methods</topic><topic>Neurologic Examination - standards</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Psychomotor Performance - physiology</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Sex Factors</topic><topic>Spectral analysis</topic><topic>Tremor - diagnosis</topic><topic>Tremor - etiology</topic><topic>Tremor - physiopathology</topic><topic>User-Computer Interface</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erasmus, Lutz-Peter</creatorcontrib><creatorcontrib>Sarno, Stefania</creatorcontrib><creatorcontrib>Albrecht, Holger</creatorcontrib><creatorcontrib>Schwecht, Martina</creatorcontrib><creatorcontrib>Pöllmann, Walter</creatorcontrib><creatorcontrib>König, Nicolaus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erasmus, Lutz-Peter</au><au>Sarno, Stefania</au><au>Albrecht, Holger</au><au>Schwecht, Martina</au><au>Pöllmann, Walter</au><au>König, Nicolaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of ataxic symptoms with a graphic tablet: standard values in controls and validity in Multiple Sclerosis patients</atitle><jtitle>Journal of neuroscience methods</jtitle><addtitle>J Neurosci Methods</addtitle><date>2001-07-15</date><risdate>2001</risdate><volume>108</volume><issue>1</issue><spage>25</spage><epage>37</epage><pages>25-37</pages><issn>0165-0270</issn><eissn>1872-678X</eissn><coden>JNMEDT</coden><abstract>Aim of our study was to find a specific measure for the intensity of upper limb tremor and other ataxic symptoms in Multiple Sclerosis (MS) patients, and to establish standard values and test quality parameters. Three hundred and forty-two consecutive patients with different symptoms in the upper limbs (upper motor neuron symptoms, cerebellar upper limb ataxia, and/or sensory deficits in the upper limbs) and 140 healthy controls took part in the study. All patients and controls had to trace over a 25 cm high figure ‘8’ on a graphic tablet, to tap with the stylus on the tablet and to perform the nine-hole-peg test (9HPT). Patients were additionally examined using clinical standard scales to classify motor dysfunctions of the upper limbs. One hundred and eighty-nine patients and 27 controls were tested twice to investigate the test reliability. Kinematic analysis of the tablet data was performed by kernel estimators, oscillatory activity by spectral analysis. Total power in the 2–10 Hz band was very specific for ataxia versus other motor symptoms. Tapping and 9HPT could well distinguish patients from controls, and patients with predominant motor neuron or cerebellar symptoms from patients with predominant sensory dysfunctions. Mean drawing error did not differ between motor and sensory dysfunctions. The test–retest reliability was similarly high for both spectral analysis and 9HPT.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11459615</pmid><doi>10.1016/S0165-0270(01)00373-9</doi><tpages>13</tpages></addata></record> |
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| subjects | Adult Age Factors Arm - innervation Arm - physiopathology Ataxia - diagnosis Ataxia - etiology Ataxia - physiopathology Biological and medical sciences Biomechanical Phenomena Cerebellar tremor Computer Graphics - instrumentation Diagnosis, Computer-Assisted - instrumentation Diagnosis, Computer-Assisted - methods Disability Evaluation Female Graphic tablet Handwriting Humans Kinematic analysis Limb ataxia Male Medical sciences Middle Aged Multiple Sclerosis Multiple Sclerosis - complications Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Muscle Spasticity - diagnosis Muscle Spasticity - etiology Muscle Spasticity - physiopathology Neurologic Examination - instrumentation Neurologic Examination - methods Neurologic Examination - standards Neurology Neuropsychological Tests Psychomotor Performance - physiology Reference Values Reproducibility of Results Sex Factors Spectral analysis Tremor - diagnosis Tremor - etiology Tremor - physiopathology User-Computer Interface |
| title | Measurement of ataxic symptoms with a graphic tablet: standard values in controls and validity in Multiple Sclerosis patients |
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