UT-A Urea Transporter Protein in Heart: Increased Abundance During Uremia, Hypertension, and Heart Failure

ABSTRACT—Urea transporters have been cloned from kidney medulla (UT-A) and erythrocytes (UT-B). We determined whether UT-A proteins could be detected in heart and whether their abundance was altered by uremia or hypertension or in human heart failure. In normal rat heart, bands were detected at 56,...

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Veröffentlicht in:	Circulation research 2001-07, Vol.89 (2), p.139-145
Hauptverfasser:	Duchesne, Rafael, Klein, Janet D, Velotta, Jeffrey B, Doran, John J, Rouillard, Patricia, Roberts, Brian R, McDonough, Alicia A, Sands, Jeff M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blotting, Western Cardiology. Vascular system Carrier Proteins - genetics Carrier Proteins - metabolism Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Heart Heart Failure - genetics Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Hypertension - genetics Hypertension - metabolism Male Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Transport Proteins Middle Aged Myocardium - metabolism Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Rats Rats, Sprague-Dawley Renal failure RNA, Messenger - genetics RNA, Messenger - metabolism Urea Transporters Uremia - genetics Uremia - metabolism
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