Role of PI3-Kinase in Isoproterenol and IGF-1 Induced ecNOS Activity

Phosphatidylinositol 3-kinase (PI3-K) has been shown to mediate insulin and insulin-like growth factor-1 (IGF-1)-induced nitric oxide (NO) generation and, thus, vascular tone. A role for PI3-K in G-protein-coupled receptor signal transduction has been reported. As beta (β2)-adrenergic vascular actio...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-07, Vol.285 (4), p.954-958
Hauptverfasser:	Isenović, Esma, Muniyappa, Ranganath, Milivojević, Nikola, Rao, Yoshida, Sowers, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - cytology Cardiotonic Agents - pharmacology Cells, Cultured endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Enzyme Induction Insulin-Like Growth Factor I - pharmacology isoproteranol Isoproterenol - pharmacology nitric oxide synthase Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type III Phosphatidylinositol 3-Kinases - metabolism PI3-kinase Rats Rats, Wistar Vasodilation - physiology
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