Association of p53 gene mutations with sensitivity to TZT‐1027 in patients with clinical lung and renal carcinoma

BACKGROUND It has been revealed that chemotherapy using DNA‐damaging agents and radiotherapy were influenced by the p53 status of tumors; however, p53 status did not influence chemotherapy using antimicrotubule agents. To elucidate whether a novel antimicrotubule agent, TZT‐1027, is influenced by th...

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Veröffentlicht in:	Cancer 2001-07, Vol.92 (2), p.386-394
Hauptverfasser:	Natsume, Tsugitaka, Kobayashi, Motohiro, Fujimoto, Shuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics DNA Damage Female General aspects Genes, p53 - genetics Humans kidney carcinoma Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics lung carcinoma Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Medical sciences Middle Aged nonsmall cell lung carcinoma Oligopeptides - pharmacology p53 status Pharmacology. Drug treatments Polymerase Chain Reaction renal cell carcinoma sensitivity Tumor Cells, Cultured TZT-1027
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