Functional characterization of Fas ligand on tumor cells escaping active specific immunotherapy

Mice transgenic for the rat HER-2/neu oncogene (rNeu-TG) developed spontaneous breast tumors that can escape a rNeu-specific immune response induced by active specific immunotherapy (ASI). The ability of these escape tumors to grow appeared to be due to upregulation of the Fas ligand (Fas-L) molecul...

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Veröffentlicht in:	Cell death and differentiation 2001-07, Vol.8 (7), p.687-695
Hauptverfasser:	Céfai, D, Schwaninger, R, Balli, M, Brunner, T, Gimmi, C D
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adenocarcinoma - genetics Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - therapy Animals Apoptosis Cell death Coculture Techniques Fas Ligand Protein FasL protein Fibroblasts Flow Cytometry Gene Expression HER2 gene Immune system Immunohistochemistry Immunotherapy Immunotherapy, Active Ligands Lymphocytes Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - immunology Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - therapy Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Transgenic Neoplasm Transplantation neu gene Phenotype Rats Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Tumor Cells, Cultured Tumors Vaccination
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