Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

New histamine H3-receptor antagonists were synthesised and tested on rat brain membranes and on electrically stimulated guinea-pig ileum. The new compounds have a central polar group represented by a 2-alkylimidazole or a 2-thioimidazoline nucleus. The effect of the polar group basicity on the optim...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2000, Vol.55 (1), p.27-34
Hauptverfasser:	MOR, M, BORDI, F, PLAZZI, P. V, SILVA, C, RIVARA, S, ZULIANI, V, VACONDIO, F, MORINI, G, BAROCELLI, E, BALLABENI, V, IMPICCIATORE, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - metabolism Electric Stimulation Guinea Pigs Histamine Antagonists - chemical synthesis Histamine Antagonists - chemistry Histamine Antagonists - pharmacology Ileum - drug effects Ileum - metabolism Imidazoles - chemistry Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Radioligand Assay Rats Rats, Wistar Receptors, Histamine H3 - drug effects
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