Postbinding fusion function contributed by a chimeric murine leukemia virus envelope protein

We previously obtained a chimeric Friend murine leukemia virus (FMLV) envelope protein (Env) in which the whole receptor-binding domain (RBD) was replaced with a surface domain of human CD4. Here, we examined if the postbinding fusion function of the CD4-Env chimera still remains to be intact. While...

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Veröffentlicht in:	Archives of virology 2001-01, Vol.146 (5), p.953-961
Hauptverfasser:	NAKAMURA, H, TAKEDA, A, MATANO, T
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - virology Animal viral diseases Animals Binding Sites Biological and medical sciences CD4 Antigens - genetics Cytopathogenic Effect, Viral - genetics Friend murine leukemia virus Friend murine leukemia virus - genetics Friend murine leukemia virus - pathogenicity Friend murine leukemia virus - physiology Fundamental and applied biological sciences. Psychology Gene Products, env - physiology Genes, env Giant Cells - virology HeLa Cells - virology Humans Infectious diseases Medical sciences Membrane Fusion - genetics Membrane Fusion - physiology Membrane Glycoproteins - metabolism Mice Microbiology NIH-3T3 cells Point Mutation Protein Structure, Tertiary Receptors, Virus - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - physiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Viral diseases Virology Virulence Virus Cultivation
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