Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas
Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are...
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| Veröffentlicht in: | Cancer letters 2001-09, Vol.170 (2), p.131-138 |
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| creator | Ko, Josephine Mun Yee Wong, Christina Pui Sze Tang, Cecilia Man Ching Lau, Kwok Wai Lung, Maria Li |
| description | Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC development. The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters. |
| doi_str_mv | 10.1016/S0304-3835(01)00577-8 |
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The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(01)00577-8</identifier><identifier>PMID: 11463490</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Asian Continental Ancestry Group ; Biological and medical sciences ; Carcinoma, Squamous Cell - genetics ; China ; Chinese ; Chromosome Mapping ; Chromosomes ; Esophageal cancer ; Esophageal Neoplasms - genetics ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. 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The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters.</description><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>China</subject><subject>Chinese</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Loss of Heterozygosity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhJ4B8QAgOgXE-1vGpQisKSJU4AGfLGY-7Rkm89SRIy68n6a6AGycf_My87zxCPFfwVoHavvsKFdRF1VbNa1BvABqti_aB2KhWl4U2LTwUmz_IhXjC_AMWqtbNY3GhVL2tagMbEa4z3c00TrJPzDIFuaeJcvp1vE0cp6NMoxzmfoqHniTucxoSp4FYxlHu9nEkJkmcDnt3S66XfDe7Ic0skfpeossYxzQ4fioeBdczPTu_l-L79Ydvu0_FzZePn3fvbwqsDEyFMehL0A6a0ivfIlJZURecdx364Ls2oCuNUV1Trx8dIGjEzjVGq9C1bXUpXp32HnJazuLJDpHXLm6kpZbVizujoV7A5gRiXu7OFOwhx8Hlo1VgV8H2XrBd7VlQ9l6wXQNenAPmbiD_d-psdAFengHH6PqQ3YiR_9lutrpc869OGC02fkbKljHSiORjJpysT_E_TX4DknybFQ</recordid><startdate>20010920</startdate><enddate>20010920</enddate><creator>Ko, Josephine Mun Yee</creator><creator>Wong, Christina Pui Sze</creator><creator>Tang, Cecilia Man Ching</creator><creator>Lau, Kwok Wai</creator><creator>Lung, Maria Li</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010920</creationdate><title>Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas</title><author>Ko, Josephine Mun Yee ; Wong, Christina Pui Sze ; Tang, Cecilia Man Ching ; Lau, Kwok Wai ; Lung, Maria Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-99cd207a052d1d8cce23ebfadabcdfdb8fca2991b5423ebb0c07ccba5971fb883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>China</topic><topic>Chinese</topic><topic>Chromosome Mapping</topic><topic>Chromosomes</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Loss of Heterozygosity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Tumor suppressor genes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ko, Josephine Mun Yee</creatorcontrib><creatorcontrib>Wong, Christina Pui Sze</creatorcontrib><creatorcontrib>Tang, Cecilia Man Ching</creatorcontrib><creatorcontrib>Lau, Kwok Wai</creatorcontrib><creatorcontrib>Lung, Maria Li</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ko, Josephine Mun Yee</au><au>Wong, Christina Pui Sze</au><au>Tang, Cecilia Man Ching</au><au>Lau, Kwok Wai</au><au>Lung, Maria Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2001-09-20</date><risdate>2001</risdate><volume>170</volume><issue>2</issue><spage>131</spage><epage>138</epage><pages>131-138</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Analysis of the loss of heterozygosity (LOH) detected by polymerase chain reaction techniques using 18 polymorphic markers localized to chromosomes 3p, 5, 17, and 18q in 40 Hong Kong Chinese esophageal squamous cell carcinoma (ESC) patients showed that multiple alterations on several chromosomes are involved in ESC development. The LOH rates detected for markers on chromosome 3 ranged from 44.0 to 85.7%, for chromosome 5 from 40.9 to 61.9%, for chromosome 17 from 40.0 to 100%, and for chromosome 18 from 38.9 to 58.3%. No significant association was observed between LOH and the clinical and histopathological parameters.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11463490</pmid><doi>10.1016/S0304-3835(01)00577-8</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cancer letters, 2001-09, Vol.170 (2), p.131-138 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Asian Continental Ancestry Group Biological and medical sciences Carcinoma, Squamous Cell - genetics China Chinese Chromosome Mapping Chromosomes Esophageal cancer Esophageal Neoplasms - genetics Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Humans Loss of Heterozygosity Male Medical sciences Middle Aged Polymerase Chain Reaction Tumor suppressor genes Tumors |
| title | Frequent loss of heterozygosity on multiple chromosomes in Chinese esophageal squamous cell carcinomas |
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