Design and Synthesis of a Highly Selective EP2-Receptor Agonist

EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE 2 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-08, Vol.11 (15), p.2025-2028
Hauptverfasser:	Tani, Kousuke, Naganawa, Atsushi, Ishida, Akiharu, Egashira, Hiromu, Sagawa, Kenji, Harada, Hiroyuki, Ogawa, Mikio, Maruyama, Takayuki, Ohuchida, Shuichi, Nakai, Hisao, Kondo, Kigen, Toda, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil - analogs & derivatives Alprostadil - chemical synthesis Animals Binding Sites - physiology Biological and medical sciences CHO Cells - metabolism Cricetinae Cyclic AMP - agonists Cyclobutanes - chemical synthesis Cyclobutanes - pharmacology Cyclopentanes - chemical synthesis Cyclopentanes - pharmacology Dinoprostone - metabolism Dinoprostone - pharmacology Drug Design Female Genital system. Reproduction Humans Ligands Medical sciences Mice Pharmacology. Drug treatments Rats Receptors, Prostaglandin E - agonists Receptors, Prostaglandin E, EP2 Subtype Sensitivity and Specificity Uterine Contraction - drug effects
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