Investigations of the effects of ethanol on warfarin binding to human serum albumin

Ethanol effects on warfarin binding to human serum albumin (HSA) have been studied by equilibrium dialysis and fluorescence methods at pH 7.4 in phosphate-buffered saline at 37 degrees C. In the presence of various amounts of ethanol fluorescence intensity of bound warfarin decreased significantly b...

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Veröffentlicht in:	Journal of biomedical science 2000-03, Vol.7 (2), p.114-121
Hauptverfasser:	Ha, C E, Petersen, C E, Park, D S, Harohalli, K, Bhagavan, N V
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Binding Sites Binding, Competitive Dialysis Ethanol - pharmacology Fluorometry Humans Kinetics Protein Binding - drug effects Serum Albumin - metabolism Warfarin - metabolism Warfarin - pharmacokinetics
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