Cytoskeletal Abnormalities in Chondrocytes with EXT1 and EXT2 Mutations

The EXT genes are a group of putative tumor suppressor genes that previously have been shown to participate in the development of hereditary multiple exostoses (HME), HME‐associated and isolated chondrosarcomas. Two HME disease genes, EXT1 and EXT2, have been identified and are expressed ubiquitousl...

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Veröffentlicht in:	Journal of bone and mineral research 2000-03, Vol.15 (3), p.442-450
Hauptverfasser:	Bernard, Mark A., Hogue, Deborah A., Cole, William G., Sanford, Tiffany, Snuggs, Mark B., Montufar‐Solis, Dina, Duke, P. Jackie, Carson, Daniel D., Scott, Allison, Barry Van Winkle, W., Hecht, Jacqueline T
Format:	Artikel
Sprache:	eng
Schlagworte:	a-Actinin Actinin - metabolism Actins - metabolism Biological and medical sciences Blotting, Western Cartilage - chemistry Cartilage - pathology Child chondrosarcoma cytoskeleton Cytoskeleton - pathology Diseases of the osteoarticular system DNA Mutational Analysis Exostoses - genetics Exostoses - pathology Exostoses, Multiple Hereditary - genetics Exostoses, Multiple Hereditary - pathology exostosis chondrocyte EXT gene EXT1/EXT2 genes hereditary multiple exostoses Humans Macromolecular Substances Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Microscopy, Confocal Microscopy, Fluorescence N-Acetylglucosaminyltransferases Protein Isoforms - metabolism Proteins - genetics Proteins - physiology Space life sciences Vimentin - metabolism α‐actin
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