Identification of Chlamydia trachomatis antigens recognized by human CD4+ T lymphocytes by screening an expression library

Identification of the immunogenic proteins that induce Chlamydia trachomatis (CT)‐specific T cell responses is crucial to the development of protective vaccines and understanding the mechanisms of chlamydia‐induced pathology. To characterize the targets of the human T cell response we have used chla...

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Veröffentlicht in:	European journal of immunology 2001-05, Vol.31 (5), p.1513-1522
Hauptverfasser:	Goodall, Jane Caroline, Yeo, Giles, Huang, Mingli, Raggiaschi, Roberto, Gaston, John Stanley Hill
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Antigen-Presenting Cells - immunology Antigens, Bacterial - genetics Antigens, Bacterial - immunology Arthritis, Reactive - immunology Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology CD4-Positive T-Lymphocytes - immunology Cells, Cultured Chaperonin 60 - genetics Chaperonin 60 - immunology Chlamydia Chlamydia trachomatis - enzymology Chlamydia trachomatis - genetics Chlamydia trachomatis - immunology Clone Cells - immunology Cloning, Molecular Expression library Gene Library Genes, Bacterial - genetics Genomic Library Humans Knee Joint - immunology Lymphocyte Activation - immunology Phosphopyruvate Hydratase - genetics Phosphopyruvate Hydratase - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Synovial Fluid - cytology Synovial Fluid - immunology T lymphocyte Vaccine
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