Eye instability induced by vestibular stimulation in rabbits
The slow compensatory phases of the vestibulo-ocular reflex (VOR) in the rabbit tend to drift and the drift reverses the direction. This periodic alternating drift (PAD) has two peculiar characteristics(1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately...
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| Veröffentlicht in: | Neuroreport 2001-07, Vol.12 (9), p.1847-1850 |
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| creator | Ferraresi, Aldo Azzena, Gian Battista Troiani, Diana |
| description | The slow compensatory phases of the vestibulo-ocular reflex (VOR) in the rabbit tend to drift and the drift reverses the direction. This periodic alternating drift (PAD) has two peculiar characteristics(1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus onset and persisting after the end of stimulation; (2) the peak velocity and period of the drift are dependent on stimulus amplitude. PAD of the rabbit has strong similarities with PAN, a periodic alternating nystagmus observed in humans with cerbellar disorders and in monkeys after nodulo-uvulectomy, although its peak velocity is smaller. It is hypothesized that PAD is due to a slight instability, caused by vestibular stimulation in darkness, of the cerebellar adaptive loop, which exerts a variable gain control on the time constant of the velocity storage integrator. |
| doi_str_mv | 10.1097/00001756-200107030-00017 |
| format | Article |
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This periodic alternating drift (PAD) has two peculiar characteristics(1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus onset and persisting after the end of stimulation; (2) the peak velocity and period of the drift are dependent on stimulus amplitude. PAD of the rabbit has strong similarities with PAN, a periodic alternating nystagmus observed in humans with cerbellar disorders and in monkeys after nodulo-uvulectomy, although its peak velocity is smaller. It is hypothesized that PAD is due to a slight instability, caused by vestibular stimulation in darkness, of the cerebellar adaptive loop, which exerts a variable gain control on the time constant of the velocity storage integrator.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200107030-00017</identifier><identifier>PMID: 11435910</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Biological and medical sciences ; Biological Clocks - physiology ; Cerebellum - physiology ; Eye Movements - physiology ; Fundamental and applied biological sciences. Psychology ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. 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This periodic alternating drift (PAD) has two peculiar characteristics(1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus onset and persisting after the end of stimulation; (2) the peak velocity and period of the drift are dependent on stimulus amplitude. PAD of the rabbit has strong similarities with PAN, a periodic alternating nystagmus observed in humans with cerbellar disorders and in monkeys after nodulo-uvulectomy, although its peak velocity is smaller. It is hypothesized that PAD is due to a slight instability, caused by vestibular stimulation in darkness, of the cerebellar adaptive loop, which exerts a variable gain control on the time constant of the velocity storage integrator.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Clocks - physiology</subject><subject>Cerebellum - physiology</subject><subject>Eye Movements - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Neural Pathways - physiology</subject><subject>Nystagmus, Pathologic - physiopathology</subject><subject>Physical Stimulation</subject><subject>Rabbits</subject><subject>Reflex, Vestibulo-Ocular - physiology</subject><subject>sensory integration</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vestibular Nuclei - physiology</subject><subject>Vestibule, Labyrinth - physiology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEQhoMotn78BdmL3lYzTbLZgBeR-gGCFwVvIcnO0mja1WRX6b83tVVP4lzmZXjmg3cIKYCeAlXyjOYAKapykjOVlNHyq7JFxsAlK4Won7bJmCqhSq4qMSJ7KT1nRFGod8kIgDOhgI7J-XSJhV-k3lgffL_MuhkcNoVdFu-Yem-HYGKRxTyL3neLTBTRWOv7dEB2WhMSHm7yPnm8mj5c3pR399e3lxd3pWPVRJa14gac5UYgGuOUVC1jyAGtbThIdE5UNVLXUnDIVOMosy1vauDUTlpr2T45Wc99jd3bkK_Sc58chmAW2A1JS6BQTbj4F4Qa5MqgDNZr0MUupYitfo1-buJSA9Uri_W3xfrHYv1Vya1Hmx2DnWPz27jxNAPHG8AkZ0IbzcL59MvxPJ-J1bF8zX10oceYXsLwgVHP0IR-pv96MfsE__CTtQ</recordid><startdate>20010703</startdate><enddate>20010703</enddate><creator>Ferraresi, Aldo</creator><creator>Azzena, Gian Battista</creator><creator>Troiani, Diana</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010703</creationdate><title>Eye instability induced by vestibular stimulation in rabbits</title><author>Ferraresi, Aldo ; Azzena, Gian Battista ; Troiani, Diana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3627-894a1cb4a5eeaac979f33e41ebbd417ecc568e0cf01ce39dc03bf4d8140b2fbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Clocks - physiology</topic><topic>Cerebellum - physiology</topic><topic>Eye Movements - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Neural Pathways - physiology</topic><topic>Nystagmus, Pathologic - physiopathology</topic><topic>Physical Stimulation</topic><topic>Rabbits</topic><topic>Reflex, Vestibulo-Ocular - physiology</topic><topic>sensory integration</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vestibular Nuclei - physiology</topic><topic>Vestibule, Labyrinth - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferraresi, Aldo</creatorcontrib><creatorcontrib>Azzena, Gian Battista</creatorcontrib><creatorcontrib>Troiani, Diana</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferraresi, Aldo</au><au>Azzena, Gian Battista</au><au>Troiani, Diana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eye instability induced by vestibular stimulation in rabbits</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2001-07-03</date><risdate>2001</risdate><volume>12</volume><issue>9</issue><spage>1847</spage><epage>1850</epage><pages>1847-1850</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>The slow compensatory phases of the vestibulo-ocular reflex (VOR) in the rabbit tend to drift and the drift reverses the direction. This periodic alternating drift (PAD) has two peculiar characteristics(1) it is induced by sinusoidal vestibular stimulation in naive animals, being evoked immediately after stimulus onset and persisting after the end of stimulation; (2) the peak velocity and period of the drift are dependent on stimulus amplitude. PAD of the rabbit has strong similarities with PAN, a periodic alternating nystagmus observed in humans with cerbellar disorders and in monkeys after nodulo-uvulectomy, although its peak velocity is smaller. It is hypothesized that PAD is due to a slight instability, caused by vestibular stimulation in darkness, of the cerebellar adaptive loop, which exerts a variable gain control on the time constant of the velocity storage integrator.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11435910</pmid><doi>10.1097/00001756-200107030-00017</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Biological Clocks - physiology Cerebellum - physiology Eye Movements - physiology Fundamental and applied biological sciences. Psychology Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Neural Pathways - physiology Nystagmus, Pathologic - physiopathology Physical Stimulation Rabbits Reflex, Vestibulo-Ocular - physiology sensory integration Vertebrates: nervous system and sense organs Vestibular Nuclei - physiology Vestibule, Labyrinth - physiology |
| title | Eye instability induced by vestibular stimulation in rabbits |
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