The circadian clock, light/dark cycle and melatonin are differentially involved in the expression of daily and photoperiodic variations in mt(1) melatonin receptors in the Siberian and Syrian hamsters
Mechanisms underlying the daily and photoperiodic variations in mt(1) melatonin receptors were investigated in the pars tuberalis (PT) and suprachiasmatic nuclei (SCN) of Siberian and Syrian hamsters. Whatever its daily profile, melatonin receptor density was strongly increased in both structures an...
Gespeichert in:
| Veröffentlicht in: | Neuroendocrinology 2001-07, Vol.74 (1), p.55-68 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 68 |
|---|---|
| container_issue | 1 |
| container_start_page | 55 |
| container_title | Neuroendocrinology |
| container_volume | 74 |
| creator | Schuster, C Gauer, F Malan, A Recio, J Pévet, P Masson-Pévet, M |
| description | Mechanisms underlying the daily and photoperiodic variations in mt(1) melatonin receptors were investigated in the pars tuberalis (PT) and suprachiasmatic nuclei (SCN) of Siberian and Syrian hamsters. Whatever its daily profile, melatonin receptor density was strongly increased in both structures and species after constant light exposure or pinealectomy, and decreased after a single melatonin injection, indicating melatonin involvement in the daily regulation of the receptor protein. This was confirmed by a strong inverse correlation between melatonin binding capacity and plasma melatonin concentration. In contrast, regulation of mt(1) mRNA appeared more complex. The circadian clock, the light/dark cycle and melatonin are all implicated in mt(1) gene daily fluctuations, but the extent of their involvement depends upon the structure and the species studied. The photoperiodic decrease in melatonin receptor density observed in short photoperiod (PT of the two hamster species and Syrian hamster SCN) seems to be the consequence of a long-term mt(1) gene repression induced by the lengthening of the melatonin peak. Altogether, these results show that during daily variations, mt(1) melatonin receptor mRNA and protein are differentially regulated, while at the photoperiodic level, the mt(1) protein status depends on mRNA transcription. |
| doi_str_mv | 10.1159/000054670 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71016097</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71016097</sourcerecordid><originalsourceid>FETCH-LOGICAL-p139t-fefcfc0986de5eb3a72b862b492610e621c1b0a5eb94e8e43db66bed01b1ff603</originalsourceid><addsrcrecordid>eNpNkMtOwzAQRb0AUSgs-AHkFQKJUjtOnGSJKl4SEgtgXfkxpgYnDrZb0T_ks3CBSsxmRrr3nhkNQseUXFJatVOSqyp5TXbQPiFFM2ENq0boIMa3rBQtK_bQiNKSVXXV7KOv5wVgZYMS2ooeK-fV-wV29nWRplqEd6zWygEWvcYdOJF8b3ssAmBtjYEAfbLCuTW2_cq7Feg84JSR8DkEiNH6HnuDtbDZs4EMC5_8AMF6bRVeiWBFyqa4yXXpjJ7_WxNAwZB8iFvok5U5mc_ckJ7WP-NCdDFBiIdo1wgX4eivj9HLzfXz7G7y8Hh7P7t6mAyUtWliwCijSNtwDRVIJupCNryQZVtwSoAXVFFJRJbaEhoomZacS9CESmoMJ2yMTn-5Q_AfS4hp3tmowDnRg1_GeU0J5aSts_Hkz7iUHej5EGwnwnq-_T37BraiiGs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71016097</pqid></control><display><type>article</type><title>The circadian clock, light/dark cycle and melatonin are differentially involved in the expression of daily and photoperiodic variations in mt(1) melatonin receptors in the Siberian and Syrian hamsters</title><source>Karger Journals</source><source>MEDLINE</source><creator>Schuster, C ; Gauer, F ; Malan, A ; Recio, J ; Pévet, P ; Masson-Pévet, M</creator><creatorcontrib>Schuster, C ; Gauer, F ; Malan, A ; Recio, J ; Pévet, P ; Masson-Pévet, M</creatorcontrib><description>Mechanisms underlying the daily and photoperiodic variations in mt(1) melatonin receptors were investigated in the pars tuberalis (PT) and suprachiasmatic nuclei (SCN) of Siberian and Syrian hamsters. Whatever its daily profile, melatonin receptor density was strongly increased in both structures and species after constant light exposure or pinealectomy, and decreased after a single melatonin injection, indicating melatonin involvement in the daily regulation of the receptor protein. This was confirmed by a strong inverse correlation between melatonin binding capacity and plasma melatonin concentration. In contrast, regulation of mt(1) mRNA appeared more complex. The circadian clock, the light/dark cycle and melatonin are all implicated in mt(1) gene daily fluctuations, but the extent of their involvement depends upon the structure and the species studied. The photoperiodic decrease in melatonin receptor density observed in short photoperiod (PT of the two hamster species and Syrian hamster SCN) seems to be the consequence of a long-term mt(1) gene repression induced by the lengthening of the melatonin peak. Altogether, these results show that during daily variations, mt(1) melatonin receptor mRNA and protein are differentially regulated, while at the photoperiodic level, the mt(1) protein status depends on mRNA transcription.</description><identifier>ISSN: 0028-3835</identifier><identifier>DOI: 10.1159/000054670</identifier><identifier>PMID: 11435758</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Animals ; Antisense Elements (Genetics) - metabolism ; Biological Clocks - physiology ; Circadian Rhythm - physiology ; Cricetinae ; In Situ Hybridization ; Male ; Melatonin - blood ; Melatonin - metabolism ; Melatonin - pharmacology ; Mesocricetus ; Phodopus ; Photoperiod ; Pineal Gland - surgery ; Pituitary Gland - anatomy & histology ; Pituitary Gland - drug effects ; Pituitary Gland - metabolism ; Radioligand Assay ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Receptors, Cytoplasmic and Nuclear - genetics ; Receptors, Cytoplasmic and Nuclear - metabolism ; Receptors, Melatonin ; Suprachiasmatic Nucleus - drug effects ; Suprachiasmatic Nucleus - metabolism</subject><ispartof>Neuroendocrinology, 2001-07, Vol.74 (1), p.55-68</ispartof><rights>Copyright 2001 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11435758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schuster, C</creatorcontrib><creatorcontrib>Gauer, F</creatorcontrib><creatorcontrib>Malan, A</creatorcontrib><creatorcontrib>Recio, J</creatorcontrib><creatorcontrib>Pévet, P</creatorcontrib><creatorcontrib>Masson-Pévet, M</creatorcontrib><title>The circadian clock, light/dark cycle and melatonin are differentially involved in the expression of daily and photoperiodic variations in mt(1) melatonin receptors in the Siberian and Syrian hamsters</title><title>Neuroendocrinology</title><addtitle>Neuroendocrinology</addtitle><description>Mechanisms underlying the daily and photoperiodic variations in mt(1) melatonin receptors were investigated in the pars tuberalis (PT) and suprachiasmatic nuclei (SCN) of Siberian and Syrian hamsters. Whatever its daily profile, melatonin receptor density was strongly increased in both structures and species after constant light exposure or pinealectomy, and decreased after a single melatonin injection, indicating melatonin involvement in the daily regulation of the receptor protein. This was confirmed by a strong inverse correlation between melatonin binding capacity and plasma melatonin concentration. In contrast, regulation of mt(1) mRNA appeared more complex. The circadian clock, the light/dark cycle and melatonin are all implicated in mt(1) gene daily fluctuations, but the extent of their involvement depends upon the structure and the species studied. The photoperiodic decrease in melatonin receptor density observed in short photoperiod (PT of the two hamster species and Syrian hamster SCN) seems to be the consequence of a long-term mt(1) gene repression induced by the lengthening of the melatonin peak. Altogether, these results show that during daily variations, mt(1) melatonin receptor mRNA and protein are differentially regulated, while at the photoperiodic level, the mt(1) protein status depends on mRNA transcription.</description><subject>Animals</subject><subject>Antisense Elements (Genetics) - metabolism</subject><subject>Biological Clocks - physiology</subject><subject>Circadian Rhythm - physiology</subject><subject>Cricetinae</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Melatonin - blood</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - pharmacology</subject><subject>Mesocricetus</subject><subject>Phodopus</subject><subject>Photoperiod</subject><subject>Pineal Gland - surgery</subject><subject>Pituitary Gland - anatomy & histology</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - metabolism</subject><subject>Radioligand Assay</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Cytoplasmic and Nuclear - genetics</subject><subject>Receptors, Cytoplasmic and Nuclear - metabolism</subject><subject>Receptors, Melatonin</subject><subject>Suprachiasmatic Nucleus - drug effects</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><issn>0028-3835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRb0AUSgs-AHkFQKJUjtOnGSJKl4SEgtgXfkxpgYnDrZb0T_ks3CBSsxmRrr3nhkNQseUXFJatVOSqyp5TXbQPiFFM2ENq0boIMa3rBQtK_bQiNKSVXXV7KOv5wVgZYMS2ooeK-fV-wV29nWRplqEd6zWygEWvcYdOJF8b3ssAmBtjYEAfbLCuTW2_cq7Feg84JSR8DkEiNH6HnuDtbDZs4EMC5_8AMF6bRVeiWBFyqa4yXXpjJ7_WxNAwZB8iFvok5U5mc_ckJ7WP-NCdDFBiIdo1wgX4eivj9HLzfXz7G7y8Hh7P7t6mAyUtWliwCijSNtwDRVIJupCNryQZVtwSoAXVFFJRJbaEhoomZacS9CESmoMJ2yMTn-5Q_AfS4hp3tmowDnRg1_GeU0J5aSts_Hkz7iUHej5EGwnwnq-_T37BraiiGs</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Schuster, C</creator><creator>Gauer, F</creator><creator>Malan, A</creator><creator>Recio, J</creator><creator>Pévet, P</creator><creator>Masson-Pévet, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200107</creationdate><title>The circadian clock, light/dark cycle and melatonin are differentially involved in the expression of daily and photoperiodic variations in mt(1) melatonin receptors in the Siberian and Syrian hamsters</title><author>Schuster, C ; Gauer, F ; Malan, A ; Recio, J ; Pévet, P ; Masson-Pévet, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-fefcfc0986de5eb3a72b862b492610e621c1b0a5eb94e8e43db66bed01b1ff603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antisense Elements (Genetics) - metabolism</topic><topic>Biological Clocks - physiology</topic><topic>Circadian Rhythm - physiology</topic><topic>Cricetinae</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Melatonin - blood</topic><topic>Melatonin - metabolism</topic><topic>Melatonin - pharmacology</topic><topic>Mesocricetus</topic><topic>Phodopus</topic><topic>Photoperiod</topic><topic>Pineal Gland - surgery</topic><topic>Pituitary Gland - anatomy & histology</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - metabolism</topic><topic>Radioligand Assay</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Cytoplasmic and Nuclear - genetics</topic><topic>Receptors, Cytoplasmic and Nuclear - metabolism</topic><topic>Receptors, Melatonin</topic><topic>Suprachiasmatic Nucleus - drug effects</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schuster, C</creatorcontrib><creatorcontrib>Gauer, F</creatorcontrib><creatorcontrib>Malan, A</creatorcontrib><creatorcontrib>Recio, J</creatorcontrib><creatorcontrib>Pévet, P</creatorcontrib><creatorcontrib>Masson-Pévet, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schuster, C</au><au>Gauer, F</au><au>Malan, A</au><au>Recio, J</au><au>Pévet, P</au><au>Masson-Pévet, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The circadian clock, light/dark cycle and melatonin are differentially involved in the expression of daily and photoperiodic variations in mt(1) melatonin receptors in the Siberian and Syrian hamsters</atitle><jtitle>Neuroendocrinology</jtitle><addtitle>Neuroendocrinology</addtitle><date>2001-07</date><risdate>2001</risdate><volume>74</volume><issue>1</issue><spage>55</spage><epage>68</epage><pages>55-68</pages><issn>0028-3835</issn><abstract>Mechanisms underlying the daily and photoperiodic variations in mt(1) melatonin receptors were investigated in the pars tuberalis (PT) and suprachiasmatic nuclei (SCN) of Siberian and Syrian hamsters. Whatever its daily profile, melatonin receptor density was strongly increased in both structures and species after constant light exposure or pinealectomy, and decreased after a single melatonin injection, indicating melatonin involvement in the daily regulation of the receptor protein. This was confirmed by a strong inverse correlation between melatonin binding capacity and plasma melatonin concentration. In contrast, regulation of mt(1) mRNA appeared more complex. The circadian clock, the light/dark cycle and melatonin are all implicated in mt(1) gene daily fluctuations, but the extent of their involvement depends upon the structure and the species studied. The photoperiodic decrease in melatonin receptor density observed in short photoperiod (PT of the two hamster species and Syrian hamster SCN) seems to be the consequence of a long-term mt(1) gene repression induced by the lengthening of the melatonin peak. Altogether, these results show that during daily variations, mt(1) melatonin receptor mRNA and protein are differentially regulated, while at the photoperiodic level, the mt(1) protein status depends on mRNA transcription.</abstract><cop>Switzerland</cop><pmid>11435758</pmid><doi>10.1159/000054670</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3835 |
| ispartof | Neuroendocrinology, 2001-07, Vol.74 (1), p.55-68 |
| issn | 0028-3835 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71016097 |
| source | Karger Journals; MEDLINE |
| subjects | Animals Antisense Elements (Genetics) - metabolism Biological Clocks - physiology Circadian Rhythm - physiology Cricetinae In Situ Hybridization Male Melatonin - blood Melatonin - metabolism Melatonin - pharmacology Mesocricetus Phodopus Photoperiod Pineal Gland - surgery Pituitary Gland - anatomy & histology Pituitary Gland - drug effects Pituitary Gland - metabolism Radioligand Assay Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Melatonin Suprachiasmatic Nucleus - drug effects Suprachiasmatic Nucleus - metabolism |
| title | The circadian clock, light/dark cycle and melatonin are differentially involved in the expression of daily and photoperiodic variations in mt(1) melatonin receptors in the Siberian and Syrian hamsters |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T21%3A23%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20circadian%20clock,%20light/dark%20cycle%20and%20melatonin%20are%20differentially%20involved%20in%20the%20expression%20of%20daily%20and%20photoperiodic%20variations%20in%20mt(1)%20melatonin%20receptors%20in%20the%20Siberian%20and%20Syrian%20hamsters&rft.jtitle=Neuroendocrinology&rft.au=Schuster,%20C&rft.date=2001-07&rft.volume=74&rft.issue=1&rft.spage=55&rft.epage=68&rft.pages=55-68&rft.issn=0028-3835&rft_id=info:doi/10.1159/000054670&rft_dat=%3Cproquest_pubme%3E71016097%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71016097&rft_id=info:pmid/11435758&rfr_iscdi=true |