Rikkunshi-to Raises Levels of Somatostatin and Gastrin in Human Plasma
Rikkunshi-to, a traditional Chinese (Kampo) medicine, has been used to treat chronic hypofunctions of the gastrointestinal tract. The effects of Rikkunshi-to on the plasma levels of gut-regulated peptide (somatostatin, motilin, gastrin, and vasoactive intestinal peptide (VIP)) levels were studied in...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2001, Vol.24(7), pp.841-843 |
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| creator | NAITO, Takafumi ITOH, Hiroki YASUNAGA, Fumitaka TAKEYAMA, Masaharu |
| description | Rikkunshi-to, a traditional Chinese (Kampo) medicine, has been used to treat chronic hypofunctions of the gastrointestinal tract. The effects of Rikkunshi-to on the plasma levels of gut-regulated peptide (somatostatin, motilin, gastrin, and vasoactive intestinal peptide (VIP)) levels were studied in healthy subjects. A single oral administration of Rikkunshi-to caused significant increases in plasma somatostatin and gastrin levels at 60 to 240 min compared with a placebo group. On the other hand, this medicine showed no effects on motilin and VIP levels. In conclusion, these results might indicate that the pharmacological action of Rikkunshi-to is closely related to changes in somatostatin- and gastrin-immunoreactive substance levels. |
| doi_str_mv | 10.1248/bpb.24.841 |
| format | Article |
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The effects of Rikkunshi-to on the plasma levels of gut-regulated peptide (somatostatin, motilin, gastrin, and vasoactive intestinal peptide (VIP)) levels were studied in healthy subjects. A single oral administration of Rikkunshi-to caused significant increases in plasma somatostatin and gastrin levels at 60 to 240 min compared with a placebo group. On the other hand, this medicine showed no effects on motilin and VIP levels. In conclusion, these results might indicate that the pharmacological action of Rikkunshi-to is closely related to changes in somatostatin- and gastrin-immunoreactive substance levels.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.24.841</identifier><identifier>PMID: 11456128</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Adult ; Biological and medical sciences ; Drugs, Chinese Herbal - pharmacology ; gastrin ; Gastrins - blood ; Humans ; Immunoenzyme Techniques ; Kampo ; Male ; Medical sciences ; Motilin - blood ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychodysleptics: hallucinogen ; Psychology. Psychoanalysis. 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The effects of Rikkunshi-to on the plasma levels of gut-regulated peptide (somatostatin, motilin, gastrin, and vasoactive intestinal peptide (VIP)) levels were studied in healthy subjects. A single oral administration of Rikkunshi-to caused significant increases in plasma somatostatin and gastrin levels at 60 to 240 min compared with a placebo group. On the other hand, this medicine showed no effects on motilin and VIP levels. In conclusion, these results might indicate that the pharmacological action of Rikkunshi-to is closely related to changes in somatostatin- and gastrin-immunoreactive substance levels.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>gastrin</subject><subject>Gastrins - blood</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Kampo</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motilin - blood</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychodysleptics: hallucinogen</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rikkunshi-to</subject><subject>somatostatin</subject><subject>Somatostatin - blood</subject><subject>Stimulation, Chemical</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNtKxDAQhoMouh5ufAApKF4IXZM0adorEdFVWFB078Mkm2jXHtZMK_j2RnY9IIRkYD7-mXyEHDI6ZlwU52ZpxlyMC8E2yIhlQqWSM7lJRrRkRZozWeyQXcQFpVRRnm2THcaEzBkvRuTmsXp9HVp8qdK-Sx6hQofJ1L27GpPOJ09dA32HPfRVm0A7TyaAfYh1PLdDA23yUAM2sE-2PNToDtbvHpndXM-ubtPp_eTu6nKaWqnKPs2MErxguZXUUiFtCX4uQXEujAVFjaMUcgvSe-FdCUrILDfSWGastD7L9sjpKnYZurfBYa-bCq2ra2hdN6BWjMbfZjyCx__ARTeENq6mmRBRS8noV9zZirKhQwzO62WoGggfmlH9pVZHtZoLHdVG-GgdOZjGzX_RtcsInKwBQAu1D9DaCv9EKkULEbGLFbaIWp_dTx9CX9nafY9UqytO_unYFwjatdknaFKW2A</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>NAITO, Takafumi</creator><creator>ITOH, Hiroki</creator><creator>YASUNAGA, Fumitaka</creator><creator>TAKEYAMA, Masaharu</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Rikkunshi-to Raises Levels of Somatostatin and Gastrin in Human Plasma</title><author>NAITO, Takafumi ; ITOH, Hiroki ; YASUNAGA, Fumitaka ; TAKEYAMA, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-3b742816c50c045c9afd5a7224bca70be00a6ca5ff4fe9a74536b5bc1bc5cf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>gastrin</topic><topic>Gastrins - blood</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Kampo</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motilin - blood</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychodysleptics: hallucinogen</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rikkunshi-to</topic><topic>somatostatin</topic><topic>Somatostatin - blood</topic><topic>Stimulation, Chemical</topic><topic>Vasoactive Intestinal Peptide - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAITO, Takafumi</creatorcontrib><creatorcontrib>ITOH, Hiroki</creatorcontrib><creatorcontrib>YASUNAGA, Fumitaka</creatorcontrib><creatorcontrib>TAKEYAMA, Masaharu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAITO, Takafumi</au><au>ITOH, Hiroki</au><au>YASUNAGA, Fumitaka</au><au>TAKEYAMA, Masaharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rikkunshi-to Raises Levels of Somatostatin and Gastrin in Human Plasma</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>24</volume><issue>7</issue><spage>841</spage><epage>843</epage><pages>841-843</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Rikkunshi-to, a traditional Chinese (Kampo) medicine, has been used to treat chronic hypofunctions of the gastrointestinal tract. The effects of Rikkunshi-to on the plasma levels of gut-regulated peptide (somatostatin, motilin, gastrin, and vasoactive intestinal peptide (VIP)) levels were studied in healthy subjects. A single oral administration of Rikkunshi-to caused significant increases in plasma somatostatin and gastrin levels at 60 to 240 min compared with a placebo group. On the other hand, this medicine showed no effects on motilin and VIP levels. In conclusion, these results might indicate that the pharmacological action of Rikkunshi-to is closely related to changes in somatostatin- and gastrin-immunoreactive substance levels.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11456128</pmid><doi>10.1248/bpb.24.841</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Drugs, Chinese Herbal - pharmacology gastrin Gastrins - blood Humans Immunoenzyme Techniques Kampo Male Medical sciences Motilin - blood Neuropharmacology Pharmacology. Drug treatments Psychodysleptics: hallucinogen Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rikkunshi-to somatostatin Somatostatin - blood Stimulation, Chemical Vasoactive Intestinal Peptide - metabolism |
| title | Rikkunshi-to Raises Levels of Somatostatin and Gastrin in Human Plasma |
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