Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression

Overload-induced heart failure is associated with myocyte apoptosis induced by unknown mechanisms. Wnt genes encode secreted signaling molecules that bind to frizzled receptors and stabilize cytosolic beta-catenin which is translocated into the nucleus, acts as transcriptional activator and imparts...

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Veröffentlicht in:	Cardiovascular research 2000-02, Vol.45 (3), p.720-728
Hauptverfasser:	Schumann, H, Holtz, J, Zerkowski, H R, Hatzfeld, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis beta Catenin Blotting, Western Case-Control Studies Cytoskeletal Proteins - analysis Female Gene Expression Heart Failure - metabolism Heart Failure - physiopathology Humans Male Membrane Proteins Middle Aged Myocardium - metabolism Proteins - genetics Receptors, Cell Surface - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Trans-Activators
Online-Zugang:	Volltext
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