Defects in Pulmonary Vasculature and Perinatal Lung Hemorrhage in Mice Heterozygous Null for the Forkhead Box f1 Transcription Factor

Decreased pulmonary expression of Forkhead Box f1 (Foxf1) transcription factor was associated with lethal alveolar hemorrhage in 55% of the Foxf1 +/− newborn mice. The severity of the pulmonary abnormalities correlates with the levels of Foxf1 mRNA. Defects in alveolarization and vasculogenesis were...

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Veröffentlicht in:	Developmental biology 2001-07, Vol.235 (2), p.489-506
Hauptverfasser:	Kalinichenko, Vladimir V., Lim, Lorena, Stolz, Donna Beer, Shin, Brian, Rausa, Francisco M., Clark, Jean, Whitsett, Jeffrey A., Watkins, Simon C., Costa, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles alveolar endothelial cell Animals Apoptosis beta-Galactosidase - metabolism Blotting, Western Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - metabolism bronchiolar smooth muscle cells DNA, Complementary - metabolism DNA-Binding Proteins Dose-Response Relationship, Drug Endothelial Growth Factors - metabolism Endothelium - metabolism Forkhead Transcription Factors Foxf1 Freac-1 Hemorrhage Heterozygote HFH-8 Immunohistochemistry In Situ Nick-End Labeling Lung - embryology Lung - metabolism Lung - pathology Lymphokines - metabolism Mice Mice, Knockout Microscopy, Electron Models, Genetic Mutation Oligonucleotide Array Sequence Analysis PECAM-1 Phenotype Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Receptor Protein-Tyrosine Kinases - metabolism Receptors, Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor RNA, Messenger - metabolism Trans-Activators - metabolism Transcription Factors - biosynthesis Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Type I epithelial cell Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors winged-helix transcription factor
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