Factor V Leiden and Prothrombin G20210A in Relation to Arterial and/or Vein Rethrombosis: Two Cases
The factor V Leiden (FV Leiden) and prothrombin G20210A mutations, are the most common established genetic risk factors for deep vein thrombosis (DVT). However, the relationship. between these mutations and arterial thrombotic syndromes (coronary heart disease, myocardial infarction, stroke) has not...
Gespeichert in:
| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2001-07, Vol.7 (3), p.234-237 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 237 |
|---|---|
| container_issue | 3 |
| container_start_page | 234 |
| container_title | Clinical and applied thrombosis/hemostasis |
| container_volume | 7 |
| creator | Mira, Yolanda Todolí, José Alonso, Rosario Micó, Ma Luisa Vayá, Amparo Ferrando, Fernando Estellés, Amparo Villa, Piedad Aznar, Justo |
| description | The factor V Leiden (FV Leiden) and prothrombin G20210A mutations, are the most common established genetic risk factors for deep vein thrombosis (DVT). However, the relationship. between these mutations and arterial thrombotic syndromes (coronary heart disease, myocardial infarction, stroke) has not been established. Some studies have suggested a relationship between them, but other authors have considered it unlikely that these anomalies are a major risk factor for arterial thrombosis. From the clinical point of view, a question arises concerning the risk of repeated thrombosis in patients carrying one of these two mutations. The question is whether the recurrence is attributable to the mutations or to the presence of additional circumstantial risk factors. As the risk of repeated thrombosis varies considerably from one patient to another, decisions about long-term treatment require weighing the persistence of risk factors for vascular disease (venous and arterial), especially in selected cases such as young patients or patients with thrombosis of unusual localization. |
| doi_str_mv | 10.1177/107602960100700310 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_miscellaneous_71012815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_107602960100700310</sage_id><sourcerecordid>71012815</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-dc6ad8fa02e8f15da73f3382493e67fcf3e8ccfadaafbd872f473fb77af5345a3</originalsourceid><addsrcrecordid>eNp90V1LwzAUBuAgivPrD3ghAcG7unOStmm9G8NNYaDI9LacpYlWumYmHeK_t3WDgYJXORfP-ybkMHaOcI2o1BBBpSDyFBBAAUiEPXaEucwioYTc7-YORL0YsOMQ3gEwT_P0kA0Q4xjzLD1iekK6dZ6_8JmpStNwakr-6F375t1yUTV8KkAgjHg3Ppma2so1vHV85FvjK6p7P-zz5gdsYi5U4YbPPx0fUzDhlB1YqoM5254n7HlyOx_fRbOH6f14NIt0jNhGpU6pzCyBMJnFpCQlrZSZiHNpUmW1lSbT2lJJZBdlpoSNO7FQimwi44TkCbva9K68-1ib0BbLKmhT19QYtw6FQkCRYdLBy1_w3a19072tEDKOBSSp7JXYKO1dCN7YYuWrJfmvAqHoF1D8XUAXuthWrxdLU-4i2x_vwHADAr2a3b3_VH4DP86MOQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2344205635</pqid></control><display><type>article</type><title>Factor V Leiden and Prothrombin G20210A in Relation to Arterial and/or Vein Rethrombosis: Two Cases</title><source>Sage Journals GOLD Open Access 2024</source><creator>Mira, Yolanda ; Todolí, José ; Alonso, Rosario ; Micó, Ma Luisa ; Vayá, Amparo ; Ferrando, Fernando ; Estellés, Amparo ; Villa, Piedad ; Aznar, Justo</creator><creatorcontrib>Mira, Yolanda ; Todolí, José ; Alonso, Rosario ; Micó, Ma Luisa ; Vayá, Amparo ; Ferrando, Fernando ; Estellés, Amparo ; Villa, Piedad ; Aznar, Justo</creatorcontrib><description>The factor V Leiden (FV Leiden) and prothrombin G20210A mutations, are the most common established genetic risk factors for deep vein thrombosis (DVT). However, the relationship. between these mutations and arterial thrombotic syndromes (coronary heart disease, myocardial infarction, stroke) has not been established. Some studies have suggested a relationship between them, but other authors have considered it unlikely that these anomalies are a major risk factor for arterial thrombosis. From the clinical point of view, a question arises concerning the risk of repeated thrombosis in patients carrying one of these two mutations. The question is whether the recurrence is attributable to the mutations or to the presence of additional circumstantial risk factors. As the risk of repeated thrombosis varies considerably from one patient to another, decisions about long-term treatment require weighing the persistence of risk factors for vascular disease (venous and arterial), especially in selected cases such as young patients or patients with thrombosis of unusual localization.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/107602960100700310</identifier><identifier>PMID: 11441986</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>3' Untranslated Regions ; Adult ; Angina Pectoris - etiology ; Anticoagulants - therapeutic use ; Arthritis, Rheumatoid - complications ; Autoimmune Diseases - complications ; Cardiomyopathy, Hypertrophic - complications ; Cardiovascular disease ; Colitis, Ischemic - etiology ; Factor V - genetics ; Female ; Fingers - blood supply ; Genetic Predisposition to Disease ; Health risk assessment ; Humans ; Intracranial Embolism - etiology ; Ischemia - etiology ; Male ; Middle Aged ; Mutation ; Obesity - complications ; Postoperative Complications - etiology ; Prothrombin - genetics ; Pulmonary Embolism - etiology ; Recurrence ; Risk factors ; Smoking - adverse effects ; Thrombophilia - complications ; Thrombophilia - drug therapy ; Thrombophilia - genetics ; Thrombophlebitis - etiology ; Thrombosis ; Varicose Veins - surgery</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2001-07, Vol.7 (3), p.234-237</ispartof><rights>Copyright SAGE PUBLICATIONS, INC. Jul 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-dc6ad8fa02e8f15da73f3382493e67fcf3e8ccfadaafbd872f473fb77af5345a3</citedby><cites>FETCH-LOGICAL-c411t-dc6ad8fa02e8f15da73f3382493e67fcf3e8ccfadaafbd872f473fb77af5345a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/107602960100700310$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/107602960100700310$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/107602960100700310?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11441986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mira, Yolanda</creatorcontrib><creatorcontrib>Todolí, José</creatorcontrib><creatorcontrib>Alonso, Rosario</creatorcontrib><creatorcontrib>Micó, Ma Luisa</creatorcontrib><creatorcontrib>Vayá, Amparo</creatorcontrib><creatorcontrib>Ferrando, Fernando</creatorcontrib><creatorcontrib>Estellés, Amparo</creatorcontrib><creatorcontrib>Villa, Piedad</creatorcontrib><creatorcontrib>Aznar, Justo</creatorcontrib><title>Factor V Leiden and Prothrombin G20210A in Relation to Arterial and/or Vein Rethrombosis: Two Cases</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>The factor V Leiden (FV Leiden) and prothrombin G20210A mutations, are the most common established genetic risk factors for deep vein thrombosis (DVT). However, the relationship. between these mutations and arterial thrombotic syndromes (coronary heart disease, myocardial infarction, stroke) has not been established. Some studies have suggested a relationship between them, but other authors have considered it unlikely that these anomalies are a major risk factor for arterial thrombosis. From the clinical point of view, a question arises concerning the risk of repeated thrombosis in patients carrying one of these two mutations. The question is whether the recurrence is attributable to the mutations or to the presence of additional circumstantial risk factors. As the risk of repeated thrombosis varies considerably from one patient to another, decisions about long-term treatment require weighing the persistence of risk factors for vascular disease (venous and arterial), especially in selected cases such as young patients or patients with thrombosis of unusual localization.</description><subject>3' Untranslated Regions</subject><subject>Adult</subject><subject>Angina Pectoris - etiology</subject><subject>Anticoagulants - therapeutic use</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Autoimmune Diseases - complications</subject><subject>Cardiomyopathy, Hypertrophic - complications</subject><subject>Cardiovascular disease</subject><subject>Colitis, Ischemic - etiology</subject><subject>Factor V - genetics</subject><subject>Female</subject><subject>Fingers - blood supply</subject><subject>Genetic Predisposition to Disease</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Intracranial Embolism - etiology</subject><subject>Ischemia - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Obesity - complications</subject><subject>Postoperative Complications - etiology</subject><subject>Prothrombin - genetics</subject><subject>Pulmonary Embolism - etiology</subject><subject>Recurrence</subject><subject>Risk factors</subject><subject>Smoking - adverse effects</subject><subject>Thrombophilia - complications</subject><subject>Thrombophilia - drug therapy</subject><subject>Thrombophilia - genetics</subject><subject>Thrombophlebitis - etiology</subject><subject>Thrombosis</subject><subject>Varicose Veins - surgery</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp90V1LwzAUBuAgivPrD3ghAcG7unOStmm9G8NNYaDI9LacpYlWumYmHeK_t3WDgYJXORfP-ybkMHaOcI2o1BBBpSDyFBBAAUiEPXaEucwioYTc7-YORL0YsOMQ3gEwT_P0kA0Q4xjzLD1iekK6dZ6_8JmpStNwakr-6F375t1yUTV8KkAgjHg3Ppma2so1vHV85FvjK6p7P-zz5gdsYi5U4YbPPx0fUzDhlB1YqoM5254n7HlyOx_fRbOH6f14NIt0jNhGpU6pzCyBMJnFpCQlrZSZiHNpUmW1lSbT2lJJZBdlpoSNO7FQimwi44TkCbva9K68-1ib0BbLKmhT19QYtw6FQkCRYdLBy1_w3a19072tEDKOBSSp7JXYKO1dCN7YYuWrJfmvAqHoF1D8XUAXuthWrxdLU-4i2x_vwHADAr2a3b3_VH4DP86MOQ</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Mira, Yolanda</creator><creator>Todolí, José</creator><creator>Alonso, Rosario</creator><creator>Micó, Ma Luisa</creator><creator>Vayá, Amparo</creator><creator>Ferrando, Fernando</creator><creator>Estellés, Amparo</creator><creator>Villa, Piedad</creator><creator>Aznar, Justo</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Factor V Leiden and Prothrombin G20210A in Relation to Arterial and/or Vein Rethrombosis: Two Cases</title><author>Mira, Yolanda ; Todolí, José ; Alonso, Rosario ; Micó, Ma Luisa ; Vayá, Amparo ; Ferrando, Fernando ; Estellés, Amparo ; Villa, Piedad ; Aznar, Justo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-dc6ad8fa02e8f15da73f3382493e67fcf3e8ccfadaafbd872f473fb77af5345a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>3' Untranslated Regions</topic><topic>Adult</topic><topic>Angina Pectoris - etiology</topic><topic>Anticoagulants - therapeutic use</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Autoimmune Diseases - complications</topic><topic>Cardiomyopathy, Hypertrophic - complications</topic><topic>Cardiovascular disease</topic><topic>Colitis, Ischemic - etiology</topic><topic>Factor V - genetics</topic><topic>Female</topic><topic>Fingers - blood supply</topic><topic>Genetic Predisposition to Disease</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Intracranial Embolism - etiology</topic><topic>Ischemia - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Obesity - complications</topic><topic>Postoperative Complications - etiology</topic><topic>Prothrombin - genetics</topic><topic>Pulmonary Embolism - etiology</topic><topic>Recurrence</topic><topic>Risk factors</topic><topic>Smoking - adverse effects</topic><topic>Thrombophilia - complications</topic><topic>Thrombophilia - drug therapy</topic><topic>Thrombophilia - genetics</topic><topic>Thrombophlebitis - etiology</topic><topic>Thrombosis</topic><topic>Varicose Veins - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mira, Yolanda</creatorcontrib><creatorcontrib>Todolí, José</creatorcontrib><creatorcontrib>Alonso, Rosario</creatorcontrib><creatorcontrib>Micó, Ma Luisa</creatorcontrib><creatorcontrib>Vayá, Amparo</creatorcontrib><creatorcontrib>Ferrando, Fernando</creatorcontrib><creatorcontrib>Estellés, Amparo</creatorcontrib><creatorcontrib>Villa, Piedad</creatorcontrib><creatorcontrib>Aznar, Justo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Mira, Yolanda</au><au>Todolí, José</au><au>Alonso, Rosario</au><au>Micó, Ma Luisa</au><au>Vayá, Amparo</au><au>Ferrando, Fernando</au><au>Estellés, Amparo</au><au>Villa, Piedad</au><au>Aznar, Justo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factor V Leiden and Prothrombin G20210A in Relation to Arterial and/or Vein Rethrombosis: Two Cases</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>7</volume><issue>3</issue><spage>234</spage><epage>237</epage><pages>234-237</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>The factor V Leiden (FV Leiden) and prothrombin G20210A mutations, are the most common established genetic risk factors for deep vein thrombosis (DVT). However, the relationship. between these mutations and arterial thrombotic syndromes (coronary heart disease, myocardial infarction, stroke) has not been established. Some studies have suggested a relationship between them, but other authors have considered it unlikely that these anomalies are a major risk factor for arterial thrombosis. From the clinical point of view, a question arises concerning the risk of repeated thrombosis in patients carrying one of these two mutations. The question is whether the recurrence is attributable to the mutations or to the presence of additional circumstantial risk factors. As the risk of repeated thrombosis varies considerably from one patient to another, decisions about long-term treatment require weighing the persistence of risk factors for vascular disease (venous and arterial), especially in selected cases such as young patients or patients with thrombosis of unusual localization.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>11441986</pmid><doi>10.1177/107602960100700310</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1076-0296 |
| ispartof | Clinical and applied thrombosis/hemostasis, 2001-07, Vol.7 (3), p.234-237 |
| issn | 1076-0296 1938-2723 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71012815 |
| source | Sage Journals GOLD Open Access 2024 |
| subjects | 3' Untranslated Regions Adult Angina Pectoris - etiology Anticoagulants - therapeutic use Arthritis, Rheumatoid - complications Autoimmune Diseases - complications Cardiomyopathy, Hypertrophic - complications Cardiovascular disease Colitis, Ischemic - etiology Factor V - genetics Female Fingers - blood supply Genetic Predisposition to Disease Health risk assessment Humans Intracranial Embolism - etiology Ischemia - etiology Male Middle Aged Mutation Obesity - complications Postoperative Complications - etiology Prothrombin - genetics Pulmonary Embolism - etiology Recurrence Risk factors Smoking - adverse effects Thrombophilia - complications Thrombophilia - drug therapy Thrombophilia - genetics Thrombophlebitis - etiology Thrombosis Varicose Veins - surgery |
| title | Factor V Leiden and Prothrombin G20210A in Relation to Arterial and/or Vein Rethrombosis: Two Cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T23%3A12%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factor%20V%20Leiden%20and%20Prothrombin%20G20210A%20in%20Relation%20to%20Arterial%20and/or%20Vein%20Rethrombosis:%20Two%20Cases&rft.jtitle=Clinical%20and%20applied%20thrombosis/hemostasis&rft.au=Mira,%20Yolanda&rft.date=2001-07-01&rft.volume=7&rft.issue=3&rft.spage=234&rft.epage=237&rft.pages=234-237&rft.issn=1076-0296&rft.eissn=1938-2723&rft_id=info:doi/10.1177/107602960100700310&rft_dat=%3Cproquest_AFRWT%3E71012815%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2344205635&rft_id=info:pmid/11441986&rft_sage_id=10.1177_107602960100700310&rfr_iscdi=true |