Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein
Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length...
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| Veröffentlicht in: | Vaccine 2000-05, Vol.18 (22), p.2426-2434 |
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| container_issue | 22 |
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| container_title | Vaccine |
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| creator | Raviprakash, K. Kochel, T.J. Ewing, D. Simmons, M. Phillips, I. Hayes, C.G. Porter, K.R. |
| description | Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the
N-terminal 80% E and the other expressing prM and full length E were immunogenic in intradermally inoculated mice. The vaccinated mice produced dengue-1 specific antibodies that were both neutralizing and long lasting. Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E. |
| doi_str_mv | 10.1016/S0264-410X(99)00570-8 |
| format | Article |
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N-terminal 80% E and the other expressing prM and full length E were immunogenic in intradermally inoculated mice. The vaccinated mice produced dengue-1 specific antibodies that were both neutralizing and long lasting. Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(99)00570-8</identifier><identifier>PMID: 10738100</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibodies, Viral - biosynthesis ; Antibody response ; Base Sequence ; Biological and medical sciences ; Cell Line ; Dengue - immunology ; Dengue - prevention & control ; Dengue virus ; Dengue Virus - genetics ; Dengue Virus - immunology ; DNA Primers - genetics ; DNA vaccine ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunization ; Mice ; Mice, Inbred BALB C ; Microbiology ; Mouse ; Neutralization Tests ; Peptide Fragments - genetics ; Peptide Fragments - immunology ; Recombinant Proteins - genetics ; Recombinant Proteins - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, DNA - genetics ; Vaccines, DNA - immunology ; Vaccines, Synthetic - genetics ; Vaccines, Synthetic - immunology ; Viral Envelope Proteins - genetics ; Viral Envelope Proteins - immunology ; Viral Vaccines - genetics ; Viral Vaccines - immunology ; Virology</subject><ispartof>Vaccine, 2000-05, Vol.18 (22), p.2426-2434</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-3e8f6bd3235811a7ce38588ed8e953587532183cccd3ba8e958530bf20113d1c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X99005708$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1413403$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10738100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raviprakash, K.</creatorcontrib><creatorcontrib>Kochel, T.J.</creatorcontrib><creatorcontrib>Ewing, D.</creatorcontrib><creatorcontrib>Simmons, M.</creatorcontrib><creatorcontrib>Phillips, I.</creatorcontrib><creatorcontrib>Hayes, C.G.</creatorcontrib><creatorcontrib>Porter, K.R.</creatorcontrib><title>Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the
N-terminal 80% E and the other expressing prM and full length E were immunogenic in intradermally inoculated mice. The vaccinated mice produced dengue-1 specific antibodies that were both neutralizing and long lasting. Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E.</description><subject>Animals</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antibody response</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Dengue - immunology</subject><subject>Dengue - prevention & control</subject><subject>Dengue virus</subject><subject>Dengue Virus - genetics</subject><subject>Dengue Virus - immunology</subject><subject>DNA Primers - genetics</subject><subject>DNA vaccine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunization</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Mouse</subject><subject>Neutralization Tests</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - immunology</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, DNA - genetics</subject><subject>Vaccines, DNA - immunology</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Viral Envelope Proteins - genetics</subject><subject>Viral Envelope Proteins - immunology</subject><subject>Viral Vaccines - genetics</subject><subject>Viral Vaccines - immunology</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vEzEQhi0EomngJ4B8QIgelnrW2az3hKLSQqWKHmglbpYznk1d7XpT2xuRf4_zIeiN00ivnndm9DD2DsRnEDA__ynK-ayYgfj1qWnOhKhqUagXbAKqlkVZgXrJJn-RE3Ya46PIlITmNTsBUUsFQkzYw3Xfj35YkXfo0pYPLbfkVyPxjQtj5Gm7Jg78648F3xhE5yly-r0OFKPzK57C6NEkstx4y9ux63iX6-mBk99QN-TyOgyJnH_DXrWmi_T2OKfs_ury7uJ7cXP77fpicVOgbEQqJKl2vrSylJUCMDWSVJVSZBU1Vc7qSpagJCJauTS7UFVSLNtSAEgLKKfs42Fvvvs0Uky6dxGp64ynYYy6zvbKslEZrA4ghiHGQK1eB9ebsNUg9E6x3ivWO3-6afResd713h8PjMue7LPWwWkGPhwBE9F0bTAeXfzHzUDOhMzYlwNG2cbGUdARHXkk6wJh0nZw__nkD0iwmNo</recordid><startdate>20000508</startdate><enddate>20000508</enddate><creator>Raviprakash, K.</creator><creator>Kochel, T.J.</creator><creator>Ewing, D.</creator><creator>Simmons, M.</creator><creator>Phillips, I.</creator><creator>Hayes, C.G.</creator><creator>Porter, K.R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000508</creationdate><title>Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein</title><author>Raviprakash, K. ; Kochel, T.J. ; Ewing, D. ; Simmons, M. ; Phillips, I. ; Hayes, C.G. ; Porter, K.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-3e8f6bd3235811a7ce38588ed8e953587532183cccd3ba8e958530bf20113d1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Antibody response</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Dengue - immunology</topic><topic>Dengue - prevention & control</topic><topic>Dengue virus</topic><topic>Dengue Virus - genetics</topic><topic>Dengue Virus - immunology</topic><topic>DNA Primers - genetics</topic><topic>DNA vaccine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunization</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Mouse</topic><topic>Neutralization Tests</topic><topic>Peptide Fragments - genetics</topic><topic>Peptide Fragments - immunology</topic><topic>Recombinant Proteins - genetics</topic><topic>Recombinant Proteins - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, DNA - genetics</topic><topic>Vaccines, DNA - immunology</topic><topic>Vaccines, Synthetic - genetics</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Viral Envelope Proteins - genetics</topic><topic>Viral Envelope Proteins - immunology</topic><topic>Viral Vaccines - genetics</topic><topic>Viral Vaccines - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raviprakash, K.</creatorcontrib><creatorcontrib>Kochel, T.J.</creatorcontrib><creatorcontrib>Ewing, D.</creatorcontrib><creatorcontrib>Simmons, M.</creatorcontrib><creatorcontrib>Phillips, I.</creatorcontrib><creatorcontrib>Hayes, C.G.</creatorcontrib><creatorcontrib>Porter, K.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raviprakash, K.</au><au>Kochel, T.J.</au><au>Ewing, D.</au><au>Simmons, M.</au><au>Phillips, I.</au><au>Hayes, C.G.</au><au>Porter, K.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2000-05-08</date><risdate>2000</risdate><volume>18</volume><issue>22</issue><spage>2426</spage><epage>2434</epage><pages>2426-2434</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the
N-terminal 80% E and the other expressing prM and full length E were immunogenic in intradermally inoculated mice. The vaccinated mice produced dengue-1 specific antibodies that were both neutralizing and long lasting. Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10738100</pmid><doi>10.1016/S0264-410X(99)00570-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Antibodies, Viral - biosynthesis Antibody response Base Sequence Biological and medical sciences Cell Line Dengue - immunology Dengue - prevention & control Dengue virus Dengue Virus - genetics Dengue Virus - immunology DNA Primers - genetics DNA vaccine Fundamental and applied biological sciences. Psychology Humans Immunization Mice Mice, Inbred BALB C Microbiology Mouse Neutralization Tests Peptide Fragments - genetics Peptide Fragments - immunology Recombinant Proteins - genetics Recombinant Proteins - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Vaccines - genetics Viral Vaccines - immunology Virology |
| title | Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein |
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