Hybridization between Oxy-Peptide Nucleic Acids and DNAs:  Dependence of Hybrid Stabilities on the Chain-Lengths, Types of Base Pairs, and the Chain Directions

Oxy-peptide nucleic acids (OPNAs) of [-NH-CH(CH2-CH2-Base)-CH2-O-CH2-CO-]-type main chain with four different types of nucleobases (Base = A, G, C, and U) or with an abasic side group (X) were synthesized. Melting curves of the 1:1 hybrids of o(A n )−d(T n ) pairs with n = 6, 9, 12, and 15 showed ve...

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Veröffentlicht in:	Journal of the American Chemical Society 2001-05, Vol.123 (20), p.4653-4658
Hauptverfasser:	Kuwahara, Masayasu, Arimitsu, Miki, Shigeyasu, Masanori, Saeki, Naho, Sisido, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing Chemical Phenomena Chemistry, Physical Circular Dichroism DNA - chemistry DNA, Complementary - chemistry Nucleic Acid Hybridization - methods Oligopeptides - chemical synthesis Oligopeptides - chemistry Peptide Nucleic Acids - chemical synthesis Peptide Nucleic Acids - chemistry Temperature
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