Pharmacokinetics of Zidovudine and Lamivudine in Neonates following Coadministration of Oral Doses Every 12 Hours

A phase I, repeat‐dose, open‐label study was conducted to determine the pharmacokinetics and safety of zidovudine and lamivudine, coadministered orally every 12 hours, in 16 neonates whose mothers were infected with human immunodeficiency virus type 1 (HIV‐1). The prospective mothers had been stabil...

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Veröffentlicht in:	Journal of clinical pharmacology 2001-07, Vol.41 (7), p.732-741
Hauptverfasser:	Moodley, Daya, Pillay, Kuben, Naidoo, Kogie, Moodley, Jack, Johnson, Mark A., Moore, Katy H. P., Mudd Jr, Paul N., Pakes, Gary E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Area Under Curve Biological and medical sciences Breast Feeding Drug Combinations Enzyme-Linked Immunosorbent Assay Female Half-Life HIV Infections - prevention & control HIV Infections - transmission HIV-1 Humans Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Lamivudine - administration & dosage Lamivudine - pharmacokinetics Lamivudine - therapeutic use Medical sciences Metabolic Clearance Rate Pharmacology. Drug treatments Pregnancy Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - pharmacokinetics Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - isolation & purification Viral Load Zidovudine - administration & dosage Zidovudine - pharmacokinetics Zidovudine - therapeutic use
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