Identification of 12-Lipoxygenase Interaction with Cellular Proteins by Yeast Two-Hybrid Screening

The platelet isoform of 12-lipoxygenase (12-LOX) is expressed in a variety of human tumors. 12-LOX metabolizes arachidonic acid to 12(S)-hydroxyeicosateraenoic acid (12(S)-HETE), which induces a number of cellular responses associated with tumor progression and metastasis. Little is known about 12-L...

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Veröffentlicht in:	Biochemistry (Easton) 2000-03, Vol.39 (12), p.3185-3191
Hauptverfasser:	Tang, Keqin, Finley, Russell L, Nie, Daotai, Honn, Kenneth V
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Lipoxygenase Antigens, CD - genetics Antigens, CD - metabolism Arachidonate 12-Lipoxygenase - blood Arachidonate 12-Lipoxygenase - genetics Arachidonate 12-Lipoxygenase - metabolism Blood Platelets - enzymology Cloning, Molecular Gene Library Humans Integrin beta4 Integrins - genetics Integrins - metabolism Isoenzymes - blood Isoenzymes - genetics Isoenzymes - metabolism Keratins - genetics Keratins - metabolism Lamin Type A Lamins Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Saccharomyces cerevisiae - genetics Tumor Cells, Cultured Two-Hybrid System Techniques
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