Effects of ecabet sodium, a novel gastroprotective agent, on mucin metabolism in rat gastric mucosa
The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus...
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Veröffentlicht in: | Digestive diseases and sciences 2000-03, Vol.45 (3), p.606-613 |
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creator | ICHIKAWA, T ISHIHARA, K HAYASHIDA, H HIRUMA, H SAIGENJI, K HOTTA, K |
description | The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus mucin during five successive hours of organ culture. In contrast, mucin biosynthesis in either antrum or corpus was not susceptible to the addition of ecabet to the culture medium. Ecabet-induced stimulation of prostaglandin E2 production in the antrum was essentially the same as that seen in the corpus. In antrum treated with 100 mg/kg ecabet, immunoreactivity with three distinct anti-mucin monoclonal antibodies was found not only in the specific mucus-producing cells, but also in the secreted mucus present at the surface gel layer. These results suggest that ecabet enhances the mucin metabolism, and this stimulation occurs in both the corpus and antrum, suggesting that ecabet might be a useful tool for the further clarification of the regulatory mechanism of antral mucin synthesis. |
doi_str_mv | 10.1023/A:1005469913079 |
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Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus mucin during five successive hours of organ culture. In contrast, mucin biosynthesis in either antrum or corpus was not susceptible to the addition of ecabet to the culture medium. Ecabet-induced stimulation of prostaglandin E2 production in the antrum was essentially the same as that seen in the corpus. In antrum treated with 100 mg/kg ecabet, immunoreactivity with three distinct anti-mucin monoclonal antibodies was found not only in the specific mucus-producing cells, but also in the secreted mucus present at the surface gel layer. These results suggest that ecabet enhances the mucin metabolism, and this stimulation occurs in both the corpus and antrum, suggesting that ecabet might be a useful tool for the further clarification of the regulatory mechanism of antral mucin synthesis.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/A:1005469913079</identifier><identifier>PMID: 10749340</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Anti-Ulcer Agents - pharmacology ; Biological and medical sciences ; Digestive system ; Dinoprostone - biosynthesis ; Diterpenes - pharmacology ; Diterpenes, Abietane ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Glucosamine - metabolism ; Immunohistochemistry ; Male ; Medical sciences ; Mucins - biosynthesis ; Organ Culture Techniques ; Pharmacology. 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Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus mucin during five successive hours of organ culture. In contrast, mucin biosynthesis in either antrum or corpus was not susceptible to the addition of ecabet to the culture medium. Ecabet-induced stimulation of prostaglandin E2 production in the antrum was essentially the same as that seen in the corpus. In antrum treated with 100 mg/kg ecabet, immunoreactivity with three distinct anti-mucin monoclonal antibodies was found not only in the specific mucus-producing cells, but also in the secreted mucus present at the surface gel layer. These results suggest that ecabet enhances the mucin metabolism, and this stimulation occurs in both the corpus and antrum, suggesting that ecabet might be a useful tool for the further clarification of the regulatory mechanism of antral mucin synthesis.</description><subject>Animals</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Dinoprostone - biosynthesis</subject><subject>Diterpenes - pharmacology</subject><subject>Diterpenes, Abietane</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Glucosamine - metabolism</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mucins - biosynthesis</subject><subject>Organ Culture Techniques</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stimulation, Chemical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ICHIKAWA, T</creatorcontrib><creatorcontrib>ISHIHARA, K</creatorcontrib><creatorcontrib>HAYASHIDA, H</creatorcontrib><creatorcontrib>HIRUMA, H</creatorcontrib><creatorcontrib>SAIGENJI, K</creatorcontrib><creatorcontrib>HOTTA, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ICHIKAWA, T</au><au>ISHIHARA, K</au><au>HAYASHIDA, H</au><au>HIRUMA, H</au><au>SAIGENJI, K</au><au>HOTTA, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ecabet sodium, a novel gastroprotective agent, on mucin metabolism in rat gastric mucosa</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>45</volume><issue>3</issue><spage>606</spage><epage>613</epage><pages>606-613</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus mucin during five successive hours of organ culture. In contrast, mucin biosynthesis in either antrum or corpus was not susceptible to the addition of ecabet to the culture medium. Ecabet-induced stimulation of prostaglandin E2 production in the antrum was essentially the same as that seen in the corpus. In antrum treated with 100 mg/kg ecabet, immunoreactivity with three distinct anti-mucin monoclonal antibodies was found not only in the specific mucus-producing cells, but also in the secreted mucus present at the surface gel layer. 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subjects | Animals Anti-Ulcer Agents - pharmacology Biological and medical sciences Digestive system Dinoprostone - biosynthesis Diterpenes - pharmacology Diterpenes, Abietane Gastric Mucosa - drug effects Gastric Mucosa - metabolism Glucosamine - metabolism Immunohistochemistry Male Medical sciences Mucins - biosynthesis Organ Culture Techniques Pharmacology. Drug treatments Rats Rats, Wistar Stimulation, Chemical |
title | Effects of ecabet sodium, a novel gastroprotective agent, on mucin metabolism in rat gastric mucosa |
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