Effects of ecabet sodium, a novel gastroprotective agent, on mucin metabolism in rat gastric mucosa

The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus...

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Veröffentlicht in:Digestive diseases and sciences 2000-03, Vol.45 (3), p.606-613
Hauptverfasser: ICHIKAWA, T, ISHIHARA, K, HAYASHIDA, H, HIRUMA, H, SAIGENJI, K, HOTTA, K
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container_issue 3
container_start_page 606
container_title Digestive diseases and sciences
container_volume 45
creator ICHIKAWA, T
ISHIHARA, K
HAYASHIDA, H
HIRUMA, H
SAIGENJI, K
HOTTA, K
description The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus mucin during five successive hours of organ culture. In contrast, mucin biosynthesis in either antrum or corpus was not susceptible to the addition of ecabet to the culture medium. Ecabet-induced stimulation of prostaglandin E2 production in the antrum was essentially the same as that seen in the corpus. In antrum treated with 100 mg/kg ecabet, immunoreactivity with three distinct anti-mucin monoclonal antibodies was found not only in the specific mucus-producing cells, but also in the secreted mucus present at the surface gel layer. These results suggest that ecabet enhances the mucin metabolism, and this stimulation occurs in both the corpus and antrum, suggesting that ecabet might be a useful tool for the further clarification of the regulatory mechanism of antral mucin synthesis.
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subjects Animals
Anti-Ulcer Agents - pharmacology
Biological and medical sciences
Digestive system
Dinoprostone - biosynthesis
Diterpenes - pharmacology
Diterpenes, Abietane
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Glucosamine - metabolism
Immunohistochemistry
Male
Medical sciences
Mucins - biosynthesis
Organ Culture Techniques
Pharmacology. Drug treatments
Rats
Rats, Wistar
Stimulation, Chemical
title Effects of ecabet sodium, a novel gastroprotective agent, on mucin metabolism in rat gastric mucosa
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