Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice

Dopamine-deficient (DD) mice cannot synthesize dopamine (DA) in dopaminergic neurons due to selective inactivation of the tyrosine hydroxylase gene in those neurons. These mice become hypoactive and hypophagic and die of starvation by 4 weeks of age. We used gene therapy to ascertain where DA replac...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2001-06, Vol.30 (3), p.819-828
Hauptverfasser:	Szczypka, Mark S, Kwok, Keith, Brot, Michelle D, Marck, Brett T, Matsumoto, Alvin M, Donahue, Brian A, Palmiter, Richard D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Dietary Sucrose - pharmacology Dopamine - analysis Dopamine - biosynthesis Dopamine - genetics Dopamine Agents - pharmacology Feeding Behavior - drug effects Feeding Behavior - physiology Female Food Preferences - drug effects Food Preferences - physiology Immunohistochemistry Levodopa - pharmacology Male Mice Mice, Inbred C57BL Mice, Mutant Strains Movement - drug effects Movement - physiology Neostriatum - metabolism Nesting Behavior - drug effects Nesting Behavior - physiology Nucleus Accumbens - metabolism Recombinant Proteins - genetics Transduction, Genetic Tyrosine 3-Monooxygenase - analysis Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism
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