Transdifferentiation of the Ventral Retinal Pigmented Epithelium to Neural Retina in the Growth Arrest Specific Gene 1 Mutant

During eye development, retinal pigmented epithelium (RPE) and neural retina (NR) arise from a common origin, the optic vesicle. One of the early distinctions of RPE from NR is the reduced mitotic activity of the RPE. Growth arrest specific gene 1 (Gas1) has been documented to inhibit cell cycle pro...

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Veröffentlicht in:	Developmental biology 2001-08, Vol.236 (1), p.17-29
Hauptverfasser:	Lee, Catherine S., May, Noah R., Fan, Chen-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Blotting, Southern Blotting, Western Bromodeoxyuridine - metabolism Cell Cycle Proteins Cell Differentiation Cell Division Culture Media, Serum-Free Epithelium - embryology eye Eye - embryology Gas1 Gas1 gene Genotype GPI-Linked Proteins In Situ Hybridization Membrane Proteins - genetics Mice Models, Biological Models, Genetic Mutation Phenotype Polymerase Chain Reaction proliferation retina Retina - embryology RNA - metabolism RPE Time Factors transdifferentiation
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