G Protein-Coupled Receptor Kinases 3 and 6 Use Different Pathways to Desensitize the Endogenous M3 Muscarinic Acetylcholine Receptor in Human SH-SY5Y Cells

We have investigated the effects of G protein-coupled receptor kinase (GRK) 3 and GRK6 on the phosphorylation and regulation of the M 3 muscarinic acetylcholine receptor (mACh) endogenously expressed in SH-SY5Y cells. Overexpression of GRK3 or GRK6 enhanced M 3 mACh receptor phosphorylation after hi...

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Veröffentlicht in:	Molecular pharmacology 2001-08, Vol.60 (2), p.321-330
Hauptverfasser:	Willets, J M, Challiss, R A, Kelly, E, Nahorski, S R
Format:	Artikel
Sprache:	eng
Schlagworte:	Endocytosis G-Protein-Coupled Receptor Kinase 3 G-Protein-Coupled Receptor Kinases GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Humans Inositol Phosphates - metabolism Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptor, Muscarinic M3 Receptors, Muscarinic - metabolism Sulfur Radioisotopes Transfection Tritium Tumor Cells, Cultured
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