Identification of the DNA Binding Specificity and Potential Target Genes for the Farnesoid X-activated Receptor

The farnesoid X-activated receptor (FXR; NR1H4) is a member of the nuclear hormone receptor superfamily and functions as a heterodimer with the 9-cis-retinoic acid receptor (RXR). In order to determine the optimal DNA binding sequence for the FXR/RXR heterodimer, we have utilized the selectedand amp...

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Veröffentlicht in:	The Journal of biological chemistry 2000-04, Vol.275 (14), p.10638-10647
Hauptverfasser:	Laffitte, Bryan A., Kast, Heidi Rachelle, Nguyen, Catherine M., Zavacki, Ann Marie, Moore, David D., Edwards, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cloning, Molecular Consensus Sequence Dimerization DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism farnesoid X-activated receptors Humans Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Promoter Regions, Genetic Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Retinoic Acid - chemistry Receptors, Retinoic Acid - metabolism Recombinant Proteins - metabolism Repetitive Sequences, Nucleic Acid Retinoid X Receptors Sequence Alignment Substrate Specificity Transcription Factors - chemistry Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection Tumor Cells, Cultured
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