Prognostic Role of Thymidylate Synthase, Thymidine Phosphorylase/ Platelet-derived Endothelial Cell Growth Factor, and Proliferation Markers in Colorectal Cancer

5-Fluorouracil (5FU)-based therapy is given to patients with advanced colorectal cancer and as adjuvant treatment. Thymidylate synthase (TS) is the target for 5FU, and may have a prognostic role for the outcome of 5FU-based therapy together with proliferation markers such as p53 and Ki67. Thymidine...

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Veröffentlicht in:	Clinical cancer research 2000-03, Vol.6 (3), p.1063-1072
Hauptverfasser:	van Triest, B, Pinedo, H M, Blaauwgeers, J L, van Diest, P J, Schoenmakers, P S, Voorn, D A, Smid, K, Hoekman, K, Hoitsma, H F, Peters, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - analysis Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Endothelial Growth Factors - analysis Female Humans Immunohistochemistry Ki-67 Antigen - analysis Lymphokines - analysis Male Middle Aged Neovascularization, Pathologic - pathology Platelet Endothelial Cell Adhesion Molecule-1 - analysis Prognosis Survival Analysis Thymidine Phosphorylase - analysis Thymidine Phosphorylase - metabolism Thymidylate Synthase - analysis Thymidylate Synthase - metabolism Tumor Suppressor Protein p53 - analysis Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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