High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

Atherosclerosis is the primary cause of cardiovascular disease, and the risk for atherosclerosis is inversely proportional to circulating levels of high-density lipoprotein (HDL) cholesterol. However, the mechanisms by which HDL is atheroprotective are complex and not well understood 1 , 2 . Here we...

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Veröffentlicht in:	Nature medicine 2001-07, Vol.7 (7), p.853-857
Hauptverfasser:	Yuhanna, Ivan S., Zhu, Yan, Cox, Blair E., Hahner, Lisa D., Osborne-Lawrence, Sherri, Lu, Ping, Marcel, Yves L., Anderson, Richard G.W., Mendelsohn, Michael E., Hobbs, Helen H., Shaul, Philip W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins Atherosclerosis Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research Cardiovascular diseases CD36 Antigens - genetics CD36 Antigens - metabolism CD36 Antigens - physiology Cell Line, Transformed CHO Cells Cholesterol Cricetinae DNA Primers Endothelium Enzyme Activation High density lipoprotein Infectious Diseases Lipids Lipoproteins Lipoproteins, HDL - metabolism Medicine Membrane Proteins Metabolic Diseases Molecular Medicine Neurosciences Nitric oxide Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Ovaries Plasma Protein Binding Publishing Receptors, Immunologic Receptors, Lipoprotein Receptors, Scavenger Reverse Transcriptase Polymerase Chain Reaction Scavenger Receptors, Class B Sheep Signal transduction
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