Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice
To clarify the role of glial fibrillary acidic protein (GFAP)‐expressed glial cells in the circadian clock, we examined GFAP expression in the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) under various lighting conditions in mice. We demonstrated that GFAP expression did not s...
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| Veröffentlicht in: | Journal of neuroscience research 2000-04, Vol.60 (2), p.212-218 |
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| creator | Moriya, Takahiro Yoshinobu, Yuko Kouzu, Yasuko Katoh, Akira Gomi, Hiroshi Ikeda, Masayuki Yoshioka, Tohru Itohara, Shigeyoshi Shibata, Shigenobu |
| description | To clarify the role of glial fibrillary acidic protein (GFAP)‐expressed glial cells in the circadian clock, we examined GFAP expression in the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) under various lighting conditions in mice. We demonstrated that GFAP expression did not show daily change in the SCN under a light‐dark cycle; however, long‐term housing under constant lighting conditions led to dramatic changes in GFAP expression, i.e., a decrease in the SCN and an increase in the IGL. Furthermore, mice that had a targeted deletion in the GFAP gene (GFAP mutant mice) showed longer and more arrhythmic circadian activity rhythms in constant lighting conditions than wild‐type mice, while GFAP mutant mice exhibited stable circadian rhythms both in a light‐dark cycle and constant darkness, and showed normal entrainment to environmental light stimuli. These results suggest that the GFAP‐expressed astroglial cells in the SCN and the IGL may have some role in circadian oscillation under constant lighting conditions. J. Neurosci. Res. 60:212–218, 2000 © 2000 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1097-4547(20000415)60:2<212::AID-JNR10>3.0.CO;2-P |
| format | Article |
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We demonstrated that GFAP expression did not show daily change in the SCN under a light‐dark cycle; however, long‐term housing under constant lighting conditions led to dramatic changes in GFAP expression, i.e., a decrease in the SCN and an increase in the IGL. Furthermore, mice that had a targeted deletion in the GFAP gene (GFAP mutant mice) showed longer and more arrhythmic circadian activity rhythms in constant lighting conditions than wild‐type mice, while GFAP mutant mice exhibited stable circadian rhythms both in a light‐dark cycle and constant darkness, and showed normal entrainment to environmental light stimuli. These results suggest that the GFAP‐expressed astroglial cells in the SCN and the IGL may have some role in circadian oscillation under constant lighting conditions. J. Neurosci. Res. 60:212–218, 2000 © 2000 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/(SICI)1097-4547(20000415)60:2<212::AID-JNR10>3.0.CO;2-P</identifier><identifier>PMID: 10740226</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Astrocytes - metabolism ; circadian rhythm ; Circadian Rhythm - physiology ; gene targeting ; Geniculate Bodies - metabolism ; Glial Fibrillary Acidic Protein - metabolism ; intergeniculate leaflet ; Lighting ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Raphe Nuclei - metabolism ; suprachiasmatic nucleus ; Suprachiasmatic Nucleus - metabolism</subject><ispartof>Journal of neuroscience research, 2000-04, Vol.60 (2), p.212-218</ispartof><rights>Copyright © 2000 Wiley‐Liss, Inc.</rights><rights>Copyright 2000 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4180-10dc238f6f931fe4c72bd92459c09885897e089993789e9d13b5940e77cdb0673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-4547%2820000415%2960%3A2%3C212%3A%3AAID-JNR10%3E3.0.CO%3B2-P$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-4547%2820000415%2960%3A2%3C212%3A%3AAID-JNR10%3E3.0.CO%3B2-P$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10740226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moriya, Takahiro</creatorcontrib><creatorcontrib>Yoshinobu, Yuko</creatorcontrib><creatorcontrib>Kouzu, Yasuko</creatorcontrib><creatorcontrib>Katoh, Akira</creatorcontrib><creatorcontrib>Gomi, Hiroshi</creatorcontrib><creatorcontrib>Ikeda, Masayuki</creatorcontrib><creatorcontrib>Yoshioka, Tohru</creatorcontrib><creatorcontrib>Itohara, Shigeyoshi</creatorcontrib><creatorcontrib>Shibata, Shigenobu</creatorcontrib><title>Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>To clarify the role of glial fibrillary acidic protein (GFAP)‐expressed glial cells in the circadian clock, we examined GFAP expression in the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) under various lighting conditions in mice. We demonstrated that GFAP expression did not show daily change in the SCN under a light‐dark cycle; however, long‐term housing under constant lighting conditions led to dramatic changes in GFAP expression, i.e., a decrease in the SCN and an increase in the IGL. Furthermore, mice that had a targeted deletion in the GFAP gene (GFAP mutant mice) showed longer and more arrhythmic circadian activity rhythms in constant lighting conditions than wild‐type mice, while GFAP mutant mice exhibited stable circadian rhythms both in a light‐dark cycle and constant darkness, and showed normal entrainment to environmental light stimuli. These results suggest that the GFAP‐expressed astroglial cells in the SCN and the IGL may have some role in circadian oscillation under constant lighting conditions. J. Neurosci. Res. 60:212–218, 2000 © 2000 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Astrocytes - metabolism</subject><subject>circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>gene targeting</subject><subject>Geniculate Bodies - metabolism</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>intergeniculate leaflet</subject><subject>Lighting</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Raphe Nuclei - metabolism</subject><subject>suprachiasmatic nucleus</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9v0zAUxSMEYmXwFZCfUPuQcu38cVwmUAms65jaioHG21XqOK0hf4qdjvVr8IlxyJiQQJpfLB2de46vf573hsKYArCXw8t5Oh9RENwPo5APGbgT0mgUw4SdMMomk-n8nX---EjhdTCGcbp8xfzVA29wN_PQG0AQgx8CZUfeE2u_ugghouCxd0SBh8BYPPB-zuvrprxWlapb0hRkU-qsJIVeG12WmTmQTOpcS7IzTat0TYaz0-lqRNTNzihrVU6cltnWNP2gVGVpO01qI7NcZzUx20O7rci-zpUhsqltm7mqUm-2ra43nZLrVju9G6u0VE-9R0VWWvXs9j72Pp--_5Se-RfL2TydXvgypAn4FHLJgqSICxHQQoWSs3UuWBgJCSJJokRwBYkQIuCJUCKnwToSISjOZb6GmAfH3os-1-32fa9si5W23QJZrZq9Re5IcKDRvUbKI-Z6usSr3ihNY61RBe6MrtwvIgXsuCJ2XLFjhB0j_MMVY0CGjiui44q_uWKAgOnS6SuX_Pz2Cft1pfK_cnuQzvClN_zQpTr803tv7f9ae8FF-320tq26uYvOzDd0v8gjvFrMcMUWydmH87d4GfwCwZ3OUQ</recordid><startdate>20000415</startdate><enddate>20000415</enddate><creator>Moriya, Takahiro</creator><creator>Yoshinobu, Yuko</creator><creator>Kouzu, Yasuko</creator><creator>Katoh, Akira</creator><creator>Gomi, Hiroshi</creator><creator>Ikeda, Masayuki</creator><creator>Yoshioka, Tohru</creator><creator>Itohara, Shigeyoshi</creator><creator>Shibata, Shigenobu</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20000415</creationdate><title>Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice</title><author>Moriya, Takahiro ; Yoshinobu, Yuko ; Kouzu, Yasuko ; Katoh, Akira ; Gomi, Hiroshi ; Ikeda, Masayuki ; Yoshioka, Tohru ; Itohara, Shigeyoshi ; Shibata, Shigenobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4180-10dc238f6f931fe4c72bd92459c09885897e089993789e9d13b5940e77cdb0673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Astrocytes - metabolism</topic><topic>circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>gene targeting</topic><topic>Geniculate Bodies - metabolism</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>intergeniculate leaflet</topic><topic>Lighting</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Raphe Nuclei - metabolism</topic><topic>suprachiasmatic nucleus</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moriya, Takahiro</creatorcontrib><creatorcontrib>Yoshinobu, Yuko</creatorcontrib><creatorcontrib>Kouzu, Yasuko</creatorcontrib><creatorcontrib>Katoh, Akira</creatorcontrib><creatorcontrib>Gomi, Hiroshi</creatorcontrib><creatorcontrib>Ikeda, Masayuki</creatorcontrib><creatorcontrib>Yoshioka, Tohru</creatorcontrib><creatorcontrib>Itohara, Shigeyoshi</creatorcontrib><creatorcontrib>Shibata, Shigenobu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moriya, Takahiro</au><au>Yoshinobu, Yuko</au><au>Kouzu, Yasuko</au><au>Katoh, Akira</au><au>Gomi, Hiroshi</au><au>Ikeda, Masayuki</au><au>Yoshioka, Tohru</au><au>Itohara, Shigeyoshi</au><au>Shibata, Shigenobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>2000-04-15</date><risdate>2000</risdate><volume>60</volume><issue>2</issue><spage>212</spage><epage>218</epage><pages>212-218</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>To clarify the role of glial fibrillary acidic protein (GFAP)‐expressed glial cells in the circadian clock, we examined GFAP expression in the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) under various lighting conditions in mice. We demonstrated that GFAP expression did not show daily change in the SCN under a light‐dark cycle; however, long‐term housing under constant lighting conditions led to dramatic changes in GFAP expression, i.e., a decrease in the SCN and an increase in the IGL. Furthermore, mice that had a targeted deletion in the GFAP gene (GFAP mutant mice) showed longer and more arrhythmic circadian activity rhythms in constant lighting conditions than wild‐type mice, while GFAP mutant mice exhibited stable circadian rhythms both in a light‐dark cycle and constant darkness, and showed normal entrainment to environmental light stimuli. These results suggest that the GFAP‐expressed astroglial cells in the SCN and the IGL may have some role in circadian oscillation under constant lighting conditions. J. Neurosci. Res. 60:212–218, 2000 © 2000 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10740226</pmid><doi>10.1002/(SICI)1097-4547(20000415)60:2<212::AID-JNR10>3.0.CO;2-P</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Astrocytes - metabolism circadian rhythm Circadian Rhythm - physiology gene targeting Geniculate Bodies - metabolism Glial Fibrillary Acidic Protein - metabolism intergeniculate leaflet Lighting Male Mice Mice, Inbred C57BL Mice, Knockout Raphe Nuclei - metabolism suprachiasmatic nucleus Suprachiasmatic Nucleus - metabolism |
| title | Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice |
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