Disease Control of Uterine Cervical Cancer: Relationships to Tumor Oxygen Tension, Vascular Density, Cell Density, and Frequency of Mitosis and Apoptosis Measured before Treatment and during Radiotherapy
Identification of biological parameters of major importance for the control of malignant diseases can be useful for the design of optimal treatment regimes for individual patients. Tumor oxygen tension (pO 2 ), vascular density, cell density, and frequency of mitosis and apoptosis were measured befo...
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| Veröffentlicht in: | Clinical cancer research 2000-03, Vol.6 (3), p.1104-1112 |
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| creator | Lyng, H Sundfør, K Tropé, C Rofstad, E K |
| description | Identification
of biological parameters of major importance for the control of
malignant diseases can be useful for the design of optimal treatment
regimes for individual patients. Tumor oxygen tension
(pO 2 ), vascular density, cell density, and frequency of
mitosis and apoptosis were measured before treatment (40 patients) and
after 2 weeks of radiotherapy (22 patients) in patients with uterine
cervical cancer. The aim was to investigate whether one of the
parameters was more important for disease control than the others.
Three sets of data were considered; the pretreatment parameters, the
parameters measured after 2 weeks of radiation, and the changes in the
parameters during this time. The pO 2 was measured
polarographically; the other parameters were determined by histological
analyses of tumor biopsies. Hypoxic subvolume
( HSV 5 ), i.e. , the fraction of
pO 2 readings |
| format | Article |
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of biological parameters of major importance for the control of
malignant diseases can be useful for the design of optimal treatment
regimes for individual patients. Tumor oxygen tension
(pO 2 ), vascular density, cell density, and frequency of
mitosis and apoptosis were measured before treatment (40 patients) and
after 2 weeks of radiotherapy (22 patients) in patients with uterine
cervical cancer. The aim was to investigate whether one of the
parameters was more important for disease control than the others.
Three sets of data were considered; the pretreatment parameters, the
parameters measured after 2 weeks of radiation, and the changes in the
parameters during this time. The pO 2 was measured
polarographically; the other parameters were determined by histological
analyses of tumor biopsies. Hypoxic subvolume
( HSV 5 ), i.e. , the fraction of
pO 2 readings <5 mm Hg multiplied with tumor volume, showed
the strongest correlation to control. Patients with a small
HSV 5 before treatment had a higher control
probability after a median follow-up time of 50 months than patients
with a large HSV 5 ( P <
0.001). All other parameters or changes in parameters showed impaired
correlation to control compared with pretreatment
HSV 5 . The present results suggest that
pretreatment oxygenation is more important for disease control of
cervical cancer than the oxygenation after 2 weeks of radiotherapy or
the changes in oxygenation during this time. Moreover, vascular
density, cell density, and frequency of mitosis and apoptosis before
treatment or after 2 weeks of therapy are probably not as important as
pretreatment oxygenation as well. Although significant correlations
between disease control and some of the parameters other than
pretreatment oxygenation can occur in studies based on a large number
of patients, the specificity of these parameters in the prediction of
control is probably not as high as for oxygenation.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 10741740</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Apoptosis - radiation effects ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Cell Count - radiation effects ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Mitosis - radiation effects ; Neovascularization, Pathologic ; Oxygen - metabolism ; Partial Pressure ; Time Factors ; Uterine Cervical Neoplasms - blood supply ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>Clinical cancer research, 2000-03, Vol.6 (3), p.1104-1112</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10741740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyng, H</creatorcontrib><creatorcontrib>Sundfør, K</creatorcontrib><creatorcontrib>Tropé, C</creatorcontrib><creatorcontrib>Rofstad, E K</creatorcontrib><title>Disease Control of Uterine Cervical Cancer: Relationships to Tumor Oxygen Tension, Vascular Density, Cell Density, and Frequency of Mitosis and Apoptosis Measured before Treatment and during Radiotherapy</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Identification
of biological parameters of major importance for the control of
malignant diseases can be useful for the design of optimal treatment
regimes for individual patients. Tumor oxygen tension
(pO 2 ), vascular density, cell density, and frequency of
mitosis and apoptosis were measured before treatment (40 patients) and
after 2 weeks of radiotherapy (22 patients) in patients with uterine
cervical cancer. The aim was to investigate whether one of the
parameters was more important for disease control than the others.
Three sets of data were considered; the pretreatment parameters, the
parameters measured after 2 weeks of radiation, and the changes in the
parameters during this time. The pO 2 was measured
polarographically; the other parameters were determined by histological
analyses of tumor biopsies. Hypoxic subvolume
( HSV 5 ), i.e. , the fraction of
pO 2 readings <5 mm Hg multiplied with tumor volume, showed
the strongest correlation to control. Patients with a small
HSV 5 before treatment had a higher control
probability after a median follow-up time of 50 months than patients
with a large HSV 5 ( P <
0.001). All other parameters or changes in parameters showed impaired
correlation to control compared with pretreatment
HSV 5 . The present results suggest that
pretreatment oxygenation is more important for disease control of
cervical cancer than the oxygenation after 2 weeks of radiotherapy or
the changes in oxygenation during this time. Moreover, vascular
density, cell density, and frequency of mitosis and apoptosis before
treatment or after 2 weeks of therapy are probably not as important as
pretreatment oxygenation as well. Although significant correlations
between disease control and some of the parameters other than
pretreatment oxygenation can occur in studies based on a large number
of patients, the specificity of these parameters in the prediction of
control is probably not as high as for oxygenation.</description><subject>Adult</subject><subject>Aged</subject><subject>Apoptosis - radiation effects</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Cell Count - radiation effects</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Mitosis - radiation effects</subject><subject>Neovascularization, Pathologic</subject><subject>Oxygen - metabolism</subject><subject>Partial Pressure</subject><subject>Time Factors</subject><subject>Uterine Cervical Neoplasms - blood supply</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc9u1DAQxiMEoqXwCsgnuDSSHSfxhlu1pQWpVaVqyzWa2JONUWKHsVPIM_JSdXeLONkz30_z55tX2amoKpXLoq5epz9Xm5yXsjjJ3oXwk3NRCl6-zU6SUApV8tPs76UNCAHZ1rtIfmS-Zw8RybqUQnq0Gka2BaeRvrB7HCFa78Jg58CiZ7tl8sTu_qx7dGyHLiTxnP2AoJcRiF0-Z-J6niqN4_8InGFXhL8WdHp9bnhrow82HISL2c_H6DbNtRAa1mHvCdmOEOKELh44s6QZ9-wejPVxQIJ5fZ-96WEM-OHlPcserr7utt_ym7vr79uLm3woZBNzKTYV1KKvuegbbkrsVMdRcsWVEmUBjTSV0cmsvlC1ho3s0OgegOtuU6NBeZZ9OtadyaclQmwnG3RaERz6JbRKcF5XTZPAjy_g0k1o2pnsBLS2_-xPwOcjMNj98NsStvpgNWE6CumhrVvZinQz-QTIB5SA</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Lyng, H</creator><creator>Sundfør, K</creator><creator>Tropé, C</creator><creator>Rofstad, E K</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20000301</creationdate><title>Disease Control of Uterine Cervical Cancer: Relationships to Tumor Oxygen Tension, Vascular Density, Cell Density, and Frequency of Mitosis and Apoptosis Measured before Treatment and during Radiotherapy</title><author>Lyng, H ; Sundfør, K ; Tropé, C ; Rofstad, E K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h239t-3185a61f601f90d4eb7b0e307077142a93d5dc001f276ca83bedcfaa0cb86ede3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apoptosis - radiation effects</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Cell Count - radiation effects</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Mitosis - radiation effects</topic><topic>Neovascularization, Pathologic</topic><topic>Oxygen - metabolism</topic><topic>Partial Pressure</topic><topic>Time Factors</topic><topic>Uterine Cervical Neoplasms - blood supply</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyng, H</creatorcontrib><creatorcontrib>Sundfør, K</creatorcontrib><creatorcontrib>Tropé, C</creatorcontrib><creatorcontrib>Rofstad, E K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyng, H</au><au>Sundfør, K</au><au>Tropé, C</au><au>Rofstad, E K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disease Control of Uterine Cervical Cancer: Relationships to Tumor Oxygen Tension, Vascular Density, Cell Density, and Frequency of Mitosis and Apoptosis Measured before Treatment and during Radiotherapy</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>6</volume><issue>3</issue><spage>1104</spage><epage>1112</epage><pages>1104-1112</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Identification
of biological parameters of major importance for the control of
malignant diseases can be useful for the design of optimal treatment
regimes for individual patients. Tumor oxygen tension
(pO 2 ), vascular density, cell density, and frequency of
mitosis and apoptosis were measured before treatment (40 patients) and
after 2 weeks of radiotherapy (22 patients) in patients with uterine
cervical cancer. The aim was to investigate whether one of the
parameters was more important for disease control than the others.
Three sets of data were considered; the pretreatment parameters, the
parameters measured after 2 weeks of radiation, and the changes in the
parameters during this time. The pO 2 was measured
polarographically; the other parameters were determined by histological
analyses of tumor biopsies. Hypoxic subvolume
( HSV 5 ), i.e. , the fraction of
pO 2 readings <5 mm Hg multiplied with tumor volume, showed
the strongest correlation to control. Patients with a small
HSV 5 before treatment had a higher control
probability after a median follow-up time of 50 months than patients
with a large HSV 5 ( P <
0.001). All other parameters or changes in parameters showed impaired
correlation to control compared with pretreatment
HSV 5 . The present results suggest that
pretreatment oxygenation is more important for disease control of
cervical cancer than the oxygenation after 2 weeks of radiotherapy or
the changes in oxygenation during this time. Moreover, vascular
density, cell density, and frequency of mitosis and apoptosis before
treatment or after 2 weeks of therapy are probably not as important as
pretreatment oxygenation as well. Although significant correlations
between disease control and some of the parameters other than
pretreatment oxygenation can occur in studies based on a large number
of patients, the specificity of these parameters in the prediction of
control is probably not as high as for oxygenation.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>10741740</pmid><tpages>9</tpages></addata></record> |
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| ispartof | Clinical cancer research, 2000-03, Vol.6 (3), p.1104-1112 |
| issn | 1078-0432 1557-3265 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research; Alma/SFX Local Collection |
| subjects | Adult Aged Apoptosis - radiation effects Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Cell Count - radiation effects Disease-Free Survival Female Humans Middle Aged Mitosis - radiation effects Neovascularization, Pathologic Oxygen - metabolism Partial Pressure Time Factors Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy |
| title | Disease Control of Uterine Cervical Cancer: Relationships to Tumor Oxygen Tension, Vascular Density, Cell Density, and Frequency of Mitosis and Apoptosis Measured before Treatment and during Radiotherapy |
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