Selective determination of dopamine in the presence of ascorbic acid at an over-oxidized poly(N-acetylaniline) electrode

An over-oxidized poly(N-acetylaniline) (PNAANI)/GCE was used to determine dopamine (DA) in a large excess of ascorbic acid (AA) by differential pulse voltammetry. A linear relation between Ip and DA concentration was found over the range 5.0 x 10(-7) to 2.0 x 10(-5) M. The detection limit was 1.68 x...

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Veröffentlicht in:	Analyst (London) 2001-01, Vol.126 (6), p.736-738
Hauptverfasser:	Zheng, L, Wu, S, Lin, X, Nie, L, Rui, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Ascorbic Acid Biological and medical sciences Dopamine - analysis Electrochemistry Electrodes Fundamental and applied biological sciences. Psychology Non peptidic neurotransmitters, polyamines Other biological molecules
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Beschreibung
Zusammenfassung:	An over-oxidized poly(N-acetylaniline) (PNAANI)/GCE was used to determine dopamine (DA) in a large excess of ascorbic acid (AA) by differential pulse voltammetry. A linear relation between Ip and DA concentration was found over the range 5.0 x 10(-7) to 2.0 x 10(-5) M. The detection limit was 1.68 x 10(-8) M for S/N = 3 and 400 microM AA did not interfere with the DA determination. The high sensitivity was due to accumulation and selectivity was due to charge discrimination. The mechanism of selective determination of DA at over-oxidized PNAANI/GCE was also proposed.
ISSN:	0003-2654 1364-5528
DOI:	10.1039/b102534c