beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase

Because of increasing evidence that G protein-coupled receptors activate multiple signaling pathways, it becomes important to determine the coordination of these pathways and their physiological significance. Here we show that the beta(3)-adrenergic receptor (beta(3)AR) stimulates p38 mitogen-activa...

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Veröffentlicht in:	The Journal of biological chemistry 2001-07, Vol.276 (29), p.27077-27082
Hauptverfasser:	Cao, W, Medvedev, A V, Daniel, K W, Collins, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - enzymology Adrenergic beta-3 Receptor Agonists Carrier Proteins - genetics Colforsin - pharmacology Cyclic AMP - physiology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Dioxoles - pharmacology Enzyme Activation Enzyme Inhibitors - pharmacology Gene Expression Regulation - physiology Imidazoles - pharmacology Ion Channels Membrane Proteins - genetics Mitochondrial Proteins Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases Phosphorylation Promoter Regions, Genetic Pyridines - pharmacology Receptors, Adrenergic, beta-3 - physiology Uncoupling Protein 1
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