Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct

Human matrix metalloproteinase-2 (MMP-2) contains an array of three fibronectin type II (FII) modules postulated to interact with gelatin (denatured collagen). Here, we verify that the NMR solution structure of the third FII repeat (COL-3) is similar to that of the second FII repeat (COL-2); charact...

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Veröffentlicht in:	The Journal of biological chemistry 2001-07, Vol.276 (29), p.27613-27621
Hauptverfasser:	Briknarová, K, Gehrmann, M, Bányai, L, Tordai, H, Patthy, L, Llinás, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Crystallography, X-Ray Gelatin - metabolism Humans Matrix Metalloproteinase 2 - chemistry Matrix Metalloproteinase 2 - metabolism Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular Protein Conformation Solutions Spectrometry, Mass, Electrospray Ionization Substrate Specificity
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