Evaluation of heme oxygenase-1 as a systemic biological marker of sporadic AD

Heme oxygenase-1 (HO-1) is a 32-kDa stress protein that catalyzes the degradation of heme to biliverdin. HO-1 immunoreactivity is greatly increased in neurons and astrocytes of the hippocampus and cerebral cortex of individuals with AD and colocalizes to senile plaques and neurofibrillary tangles. W...

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Veröffentlicht in:	Neurology 2000-03, Vol.54 (6), p.1297-1304
Hauptverfasser:	Schipper, H M, Chertkow, H, Mehindate, K, Frankel, D, Melmed, C, Bergman, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - psychology Biomarkers - blood Enzyme-Linked Immunosorbent Assay Evaluation Studies as Topic Heme Oxygenase (Decyclizing) - blood Heme Oxygenase (Decyclizing) - cerebrospinal fluid Heme Oxygenase-1 Humans Membrane Proteins Middle Aged Neuropsychological Tests RNA - analysis
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