Blocking AMPA receptor desensitization prolongs spontaneous EPSC decay times and depolarizes H1 horizontal cells in carp retinal slices

Desensitization of H1 horizontal cell (H1 HC) glutamate receptors was investigated in carp retinal slices using cyclothiazide (CTZ), an inhibitor of AMPA receptor desensitization. 100 μM CTZ depolarized H1 HCs and increased the amplitude of light responses, without any prominent changes in their kin...

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Veröffentlicht in:	Neuroscience research 2001-07, Vol.40 (3), p.217-225
Hauptverfasser:	Hirasawa, Hajime, Shiells, Richard, Yamada, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptor Animals Benzothiadiazines - pharmacology Carps - anatomy & histology Carps - metabolism Cyclothiazide Desensitization Diuretics Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Heptanol - pharmacology Horizontal cell Interneurons - cytology Interneurons - drug effects Interneurons - metabolism Membrane Potentials - drug effects Membrane Potentials - physiology Organ Culture Techniques Photoreceptor Cells, Vertebrate - cytology Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - metabolism Receptors, AMPA - drug effects Receptors, AMPA - metabolism Retina Retina - cytology Retina - drug effects Retina - metabolism sEPSC Sodium Chloride Symporter Inhibitors - pharmacology Synapses - drug effects Synapses - metabolism Synapses - ultrastructure Time Factors Vision, Ocular - drug effects Vision, Ocular - physiology
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