The role of phosphoinositides in membrane transport
Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane trafficking. Recently, phosphoinositides have been found to direct the localization and activity of effector proteins containing consensus sequence motifs such as FYVE, PH and ENTH domains. In addition, recent...
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| Veröffentlicht in: | Current Opinion in Cell Biology 2001-08, Vol.13 (4), p.485-492 |
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| container_title | Current Opinion in Cell Biology |
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| creator | Simonsen, Anne Wurmser, Andrew E Emr, Scott D Stenmark, Harald |
| description | Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane trafficking. Recently, phosphoinositides have been found to direct the localization and activity of effector proteins containing consensus sequence motifs such as FYVE, PH and ENTH domains. In addition, recent results show that regulated synthesis and turnover of phosphoinositides by membrane-associated phosphoinoside kinases and phosphatases spatially restrict the location of effectors critical for cellular transport processes, such as clathrin-mediated endocytosis, autophagy, phagocytosis, macropinocytosis and biosynthetic trafficking. |
| doi_str_mv | 10.1016/S0955-0674(00)00240-4 |
| format | Article |
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| ispartof | Current Opinion in Cell Biology, 2001-08, Vol.13 (4), p.485-492 |
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| subjects | Animals Autophagy clathrin Endocytosis Endosomes - metabolism macropinocytosis Models, Biological phagocytosis Phosphatidylinositol 4,5-Diphosphate - physiology Phosphatidylinositol Phosphates - physiology Phosphatidylinositols - physiology Phosphoinositides PI3-kinase PI4-kinase Protein Biosynthesis Protein Transport secretion |
| title | The role of phosphoinositides in membrane transport |
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