Induction of Functional IL-8 Receptors by IL-4 and IL-13 in Human Monocytes

IL-8 and related Glu-Leu-Arg (ELR+) CXC chemokines are potent chemoattractants for neutrophils but not for monocytes. IL-13 and IL-4 strongly increased CXCR1 and CXCR2 chemokine receptor expression in human monocytes, macrophages, and dendritic cells. The effect was receptor- and cell type-selective...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-04, Vol.164 (7), p.3862-3869
Hauptverfasser:	Bonecchi, Raffaella, Facchetti, Fabio, Dusi, Stefano, Luini, Walter, Lissandrini, Daniele, Simmelink, Marleen, Locati, Massimo, Bernasconi, Sergio, Allavena, Paola, Brandt, Ernst, Rossi, Filippo, Mantovani, Alberto, Sozzani, Silvano
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - biosynthesis Antigens, CD - isolation & purification Antigens, CD - metabolism Antigens, CD - physiology Blotting, Northern Chemotaxis, Leukocyte CXCR1 protein CXCR2 protein Dermatitis, Atopic - immunology Dermatitis, Atopic - metabolism Free Radicals - metabolism Humans Interleukin 8 receptors Interleukin-13 - physiology Interleukin-4 - physiology Interleukin-8 - metabolism Monocytes - immunology Monocytes - metabolism Reactive Oxygen Species - metabolism Receptors, Chemokine - biosynthesis Receptors, Interleukin - biosynthesis Receptors, Interleukin - isolation & purification Receptors, Interleukin - metabolism Receptors, Interleukin - physiology Receptors, Interleukin-8A Receptors, Interleukin-8B Respiratory Burst - immunology Severe Combined Immunodeficiency - immunology Severe Combined Immunodeficiency - metabolism
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