Flexibility of Amino Acid Residues at Position Four of Nonapeptides Enhances Their Binding to Human Leucocyte Antigen (HLA) Molecules
The binding affinity of synthetic nonapeptides to human leucocyte antigens (HLA) molecules of the A0201 allotype, the most common in Caucasian, is enhanced or reduced by suitable amino acid substitutions at position 4, as a result of increased or decreased chain flexibility. A higher flexibility of...
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| Veröffentlicht in: | Zeitschrift für Naturforschung C. A journal of biosciences 2000-01, Vol.55 (1), p.109-114 |
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| container_title | Zeitschrift für Naturforschung C. A journal of biosciences |
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| creator | Chersi, Alberto Modugno, Francesca di Rosano, Laura |
| description | The binding affinity of synthetic nonapeptides to human leucocyte antigens (HLA) molecules of the A0201 allotype, the most common in Caucasian, is enhanced or reduced by suitable amino acid substitutions at position 4, as a result of increased or decreased chain flexibility. A higher flexibility of the bond at this position correlates with an easier accomodation of the fragment into the HLA groove, while rigidity of the peptide chain appears to interfere. These data are based on two lines of evidence: a) most natural high affnity ligands for HLA-A0201 possess, at position 4, flexible residues b) substitutions of such residues by rigid amino acids results in a decrease of binding affinity. |
| doi_str_mv | 10.1515/znc-2000-1-220 |
| format | Article |
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A higher flexibility of the bond at this position correlates with an easier accomodation of the fragment into the HLA groove, while rigidity of the peptide chain appears to interfere. 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| ispartof | Zeitschrift für Naturforschung C. A journal of biosciences, 2000-01, Vol.55 (1), p.109-114 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Amino Acid Sequence Binding Sites European Continental Ancestry Group HLA-A Antigens - chemistry Human Leucocyte Antigen (HLA) Humans Kinetics Oligopeptides - chemistry Peptide Binding Protein Conformation Secondary Interactions |
| title | Flexibility of Amino Acid Residues at Position Four of Nonapeptides Enhances Their Binding to Human Leucocyte Antigen (HLA) Molecules |
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