Higher Throughput Bioanalysis by Automation of a Protein Precipitation Assay Using a 96-Well Format with Detection by LC−MS/MS

Generic methodology for the automated preparation and analysis of drug levels in plasma samples within a drug discovery environment was achieved through the redesign of a protein precipitation assay to a microtiter (96−well) plate format and the application of robotic liquid handling for performance...

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Veröffentlicht in:	Analytical chemistry (Washington) 2000-03, Vol.72 (5), p.979-984
Hauptverfasser:	Watt, Alan P, Morrison, Denise, Locker, Karen L, Evans, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Automation Biological and medical sciences Blood Chemical Precipitation Chemistry Chromatography, High Pressure Liquid - methods Drugs General pharmacology Mass Spectrometry - methods Medical sciences Pharmacology. Drug treatments Plasma Proteins Proteins - chemistry Quality Control Reproducibility of Results Scientific imaging
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