Increased safety level of serotype 3 sabin oral poliomyelitis vaccine lots by improved seed virus, and tissue culture and virus infection conditions

The content of 472U to 472C revertant virus in serotype 3 oral poliomyelitis monovalent bulk vaccines can be quantified by MAPREC (Mutant Analysis by PCR and Restriction Enzyme Cleavage). Besides other wildtype reversions identified in propagated type 3 Sabin strain populations, the 472U to 472C rev...

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Veröffentlicht in:	Vaccine 2000-05, Vol.18 (22), p.2435-2443
Hauptverfasser:	Dörsam, Volker, Weimer, Thomas, Schmeel, Andreas, Hein, Berndt, Enssle, Karlheinz, Chumakov, Konstantin M, Fibi, Mathias R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Genetic Markers Genome, Viral Haplorhini Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects MAPREC Mutational analysis Oral poliovirus vaccine Point Mutation Poliovirus - classification Poliovirus - genetics Poliovirus - immunology Poliovirus Vaccine, Oral - adverse effects Poliovirus Vaccine, Oral - genetics Poliovirus Vaccine, Oral - isolation & purification Production of active biomolecules Quality control Safety Serotyping Vaccins Virulence - genetics Virus Cultivation
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