HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein repressed the transcriptional activity of wild-type p53 through its N-terminal trans-activation domain. Although Tax did not directly bind to p53, this repression required the activation of CREB pathway by Tax. In contrast to a recent r...

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Veröffentlicht in:	Oncogene 2000-03, Vol.19 (12), p.1491-1499
Hauptverfasser:	ARIUMI, Y, KAIDA, A, LIN, J.-Y, HIROTA, M, MASUI, O, YAMAOKA, S, TAYA, Y, SHIMOTOHNO, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Adult T-cell leukemia-lymphoma AIDS/HIV Binding sites Binding, Competitive Biological and medical sciences CBP protein Cell cycle Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Competition CREB-Binding Protein Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism DNA binding proteins Fundamental and applied biological sciences. Psychology Gene Products, tax - genetics Gene Products, tax - metabolism Gene Silencing Genes Genetic aspects Health aspects HTLV-I (Virus) human T-lymphotropic virus 1 Humans Kinases Leukemia Lymphocytes T Molecular and cellular biology NF-^KB protein NF-kappa B - metabolism NF-κB protein Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncoproteins Phosphorylation Physiological aspects Plasmids Risk factors Tax protein Trans-Activators - genetics Trans-Activators - metabolism Transcription activation Transcription, Genetic Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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