Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopic Identification and Characterization of the Tyrosyl Radicals in Prostaglandin H Synthase 1

The tyrosyl radicals generated in reactions of ethyl hydrogen peroxide with both native and indomethacin-pretreated prostaglandin H synthase 1 (PGHS-1) were examined by low-temperature electron paramagnetic resonance (EPR) and electron nuclear double resonance (ENDOR) spectroscopies. In the reaction...

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Veröffentlicht in:	Biochemistry (Easton) 2000-04, Vol.39 (14), p.4112-4121
Hauptverfasser:	Shi, Wenjun, Hoganson, Curtis W, Espe, Matthew, Bender, Christopher J, Babcock, Gerald T, Palmer, Graham, Kulmacz, Richard J, Tsai, Ah-lim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Electron Spin Resonance Spectroscopy Isoenzymes - chemistry Oxyphenonium Prostaglandin-Endoperoxide Synthases - chemistry
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