Reperfusion induces myocardial apoptotic cell death

The purpose of the present study was to investigate whether apoptosis is triggered during ischemia (I) and reperfusion (R) and whether I/R-induced apoptosis is correlated with changes in expression of Bcl-2 and Bax. Anesthetized open-chest dogs were divided into two groups. Group I: 7 h of permanent...

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Veröffentlicht in:	Cardiovascular research 2000-02, Vol.45 (3), p.651-660
Hauptverfasser:	Zhao, Z Q, Nakamura, M, Wang, N P, Wilcox, J N, Shearer, S, Ronson, R S, Guyton, R A, Vinten-Johansen, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis bcl-2-Associated X Protein Blotting, Western Dogs Female Heart - physiopathology Immunohistochemistry In Situ Nick-End Labeling Male Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Neutrophils - pathology Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins c-bcl-2 - analysis
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