Superiority of endothelin-1 over norepinephrine in exercise-induced alterations of the conduit artery tone of the non-exercised arm in patients with chronic heart failure
This study is aimed at examining the relative importance of norepinephrine and endothelin-1 in treadmill exercise-induced changes in brachial arterial tone of the non-exercised arm in patients with chronic heart failure (CHF). Brachial artery diameter and blood flow were measured before and after ex...
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| Veröffentlicht in: | International journal of cardiology 2000-03, Vol.73 (1), p.15-25 |
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| creator | Yousufuddin, Mohammed Shamim, Waqar Chambers, Jonathan S. Henein, Michael Amin, Fouad R. Anker, Stefan D. Kemp, Michael Hooper, James Coats, Andrew J.S. |
| description | This study is aimed at examining the relative importance of norepinephrine and endothelin-1 in treadmill exercise-induced changes in brachial arterial tone of the non-exercised arm in patients with chronic heart failure (CHF). Brachial artery diameter and blood flow were measured before and after exercise in eight healthy volunteers and 18 patients with stable chronic heart failure by high-resolution ultrasound. Maximal exercise resulted in brachial artery dilatation in controls (4.42±0.39 vs. 4.77±0.39 mm;
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| doi_str_mv | 10.1016/S0167-5273(99)00200-4 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70999240</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527399002004</els_id><sourcerecordid>70999240</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-97f3fdff16efbf48140e80d2f05f0dd3f5a1d95eae654af905a02005899158ae3</originalsourceid><addsrcrecordid>eNqFkc2OFCEUhYnROO3oI2hYGKML9NIFXcXKmIl_ySQuRteEgUsKUw0lUKP9Sj6l1HT7s3NzWdzvHG7OIeQxh5cc-O7VVRs9k9u-e67UC4AtABN3yIYPvWC8l-Iu2fxBzsiDUr4CgFBquE_OOPRi6GC3IT-vlhlzSDnUA02eYnSpjjiFyDhNN5hpTBnnEHEec5s0RIo_MNtQkIXoFouOmqliNjWkWFaPpqc2tV2o1OS2OtCamvS0iimy3xZNm_er59zkGGuh30MdqR1zisHSEZueehOmJeNDcs-bqeCj03tOvrx7-_niA7v89P7jxZtLZjsFlaned955z3for70YuAAcwG09SA_OdV4a7pREgzspjFcgzRqeHJTicjDYnZNnR985p28Llqr3oVicJhMxLUX3oJTaCmigPII2p1Iyej3nsDf5oDnotSR9W5JeG9BK6duStGi6J6cPlus9un9Ux1Ya8PQEmGLN5LOJLay_XNe1gmXDXh8xbGncBMy62BZiayRktFW7FP5zyS_sarK1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70999240</pqid></control><display><type>article</type><title>Superiority of endothelin-1 over norepinephrine in exercise-induced alterations of the conduit artery tone of the non-exercised arm in patients with chronic heart failure</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Yousufuddin, Mohammed ; Shamim, Waqar ; Chambers, Jonathan S. ; Henein, Michael ; Amin, Fouad R. ; Anker, Stefan D. ; Kemp, Michael ; Hooper, James ; Coats, Andrew J.S.</creator><creatorcontrib>Yousufuddin, Mohammed ; Shamim, Waqar ; Chambers, Jonathan S. ; Henein, Michael ; Amin, Fouad R. ; Anker, Stefan D. ; Kemp, Michael ; Hooper, James ; Coats, Andrew J.S.</creatorcontrib><description>This study is aimed at examining the relative importance of norepinephrine and endothelin-1 in treadmill exercise-induced changes in brachial arterial tone of the non-exercised arm in patients with chronic heart failure (CHF). Brachial artery diameter and blood flow were measured before and after exercise in eight healthy volunteers and 18 patients with stable chronic heart failure by high-resolution ultrasound. Maximal exercise resulted in brachial artery dilatation in controls (4.42±0.39 vs. 4.77±0.39 mm;
P<0.0001) in contrast to constriction seen in the patients (5.27±0.67 vs. 5.12±0.66 mm;
P=0.07). Both groups demonstrated a significant increase in blood flow after exercise. The pre-exercise (2.83±0.76 vs. 1.69±0.15 pmol/l;
P=0.0004), post-exercise (4.15±1.5 vs. 2.02±0.34 pmol/l;
P=0.0004) and the percent increase (47.15±32.5 vs. 19.0±10.5%;
P=0.02) in endothelin-1 levels were significantly greater in patients than in controls. In contrast to endothelin-1, the exercise-induced percent increase in norepinephrine was greater in controls than patients (100.7±51.8 vs. 49.8±43.4%;
P=0.01). The percent change in the diameter of the brachial artery in response to maximal exercise was significantly correlated to pre- (
r=0.634;
P=0.003) and post-exercise (
r=0.467;
P=0.05) endothelin-1 levels in patients but not in controls [pre-exercise (
r=0.07;
P=0.86), post-exercise (
r=0.310;
P=0.47)]. The change in the diameter of the brachial artery did not correlate with pre- or post-exercise plasma norepinephrine levels in either group. These findings suggest that endothelin-1 is potentially more important than norepinephrine in contributing exercise-induced brachial artery constriction in patients with chronic heart failure.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/S0167-5273(99)00200-4</identifier><identifier>PMID: 10748306</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Brachial Artery ; Cardiology. Vascular system ; Chronic heart failure ; Endothelin-1 ; Endothelin-1 - blood ; Endothelium, Vascular - metabolism ; Exercise ; Exercise - physiology ; Heart ; Heart Failure - blood ; Heart Failure - rehabilitation ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Hemodynamics ; Humans ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Norepinephrine ; Norepinephrine - blood ; Regional Blood Flow ; Vascular tone ; Vasoconstriction ; Vasomotor System - metabolism ; Vasomotor System - physiology</subject><ispartof>International journal of cardiology, 2000-03, Vol.73 (1), p.15-25</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-97f3fdff16efbf48140e80d2f05f0dd3f5a1d95eae654af905a02005899158ae3</citedby><cites>FETCH-LOGICAL-c390t-97f3fdff16efbf48140e80d2f05f0dd3f5a1d95eae654af905a02005899158ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0167-5273(99)00200-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1331755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10748306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yousufuddin, Mohammed</creatorcontrib><creatorcontrib>Shamim, Waqar</creatorcontrib><creatorcontrib>Chambers, Jonathan S.</creatorcontrib><creatorcontrib>Henein, Michael</creatorcontrib><creatorcontrib>Amin, Fouad R.</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Kemp, Michael</creatorcontrib><creatorcontrib>Hooper, James</creatorcontrib><creatorcontrib>Coats, Andrew J.S.</creatorcontrib><title>Superiority of endothelin-1 over norepinephrine in exercise-induced alterations of the conduit artery tone of the non-exercised arm in patients with chronic heart failure</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>This study is aimed at examining the relative importance of norepinephrine and endothelin-1 in treadmill exercise-induced changes in brachial arterial tone of the non-exercised arm in patients with chronic heart failure (CHF). Brachial artery diameter and blood flow were measured before and after exercise in eight healthy volunteers and 18 patients with stable chronic heart failure by high-resolution ultrasound. Maximal exercise resulted in brachial artery dilatation in controls (4.42±0.39 vs. 4.77±0.39 mm;
P<0.0001) in contrast to constriction seen in the patients (5.27±0.67 vs. 5.12±0.66 mm;
P=0.07). Both groups demonstrated a significant increase in blood flow after exercise. The pre-exercise (2.83±0.76 vs. 1.69±0.15 pmol/l;
P=0.0004), post-exercise (4.15±1.5 vs. 2.02±0.34 pmol/l;
P=0.0004) and the percent increase (47.15±32.5 vs. 19.0±10.5%;
P=0.02) in endothelin-1 levels were significantly greater in patients than in controls. In contrast to endothelin-1, the exercise-induced percent increase in norepinephrine was greater in controls than patients (100.7±51.8 vs. 49.8±43.4%;
P=0.01). The percent change in the diameter of the brachial artery in response to maximal exercise was significantly correlated to pre- (
r=0.634;
P=0.003) and post-exercise (
r=0.467;
P=0.05) endothelin-1 levels in patients but not in controls [pre-exercise (
r=0.07;
P=0.86), post-exercise (
r=0.310;
P=0.47)]. The change in the diameter of the brachial artery did not correlate with pre- or post-exercise plasma norepinephrine levels in either group. These findings suggest that endothelin-1 is potentially more important than norepinephrine in contributing exercise-induced brachial artery constriction in patients with chronic heart failure.</description><subject>Biological and medical sciences</subject><subject>Brachial Artery</subject><subject>Cardiology. Vascular system</subject><subject>Chronic heart failure</subject><subject>Endothelin-1</subject><subject>Endothelin-1 - blood</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Heart</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - rehabilitation</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Norepinephrine</subject><subject>Norepinephrine - blood</subject><subject>Regional Blood Flow</subject><subject>Vascular tone</subject><subject>Vasoconstriction</subject><subject>Vasomotor System - metabolism</subject><subject>Vasomotor System - physiology</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhYnROO3oI2hYGKML9NIFXcXKmIl_ySQuRteEgUsKUw0lUKP9Sj6l1HT7s3NzWdzvHG7OIeQxh5cc-O7VVRs9k9u-e67UC4AtABN3yIYPvWC8l-Iu2fxBzsiDUr4CgFBquE_OOPRi6GC3IT-vlhlzSDnUA02eYnSpjjiFyDhNN5hpTBnnEHEec5s0RIo_MNtQkIXoFouOmqliNjWkWFaPpqc2tV2o1OS2OtCamvS0iimy3xZNm_er59zkGGuh30MdqR1zisHSEZueehOmJeNDcs-bqeCj03tOvrx7-_niA7v89P7jxZtLZjsFlaned955z3for70YuAAcwG09SA_OdV4a7pREgzspjFcgzRqeHJTicjDYnZNnR985p28Llqr3oVicJhMxLUX3oJTaCmigPII2p1Iyej3nsDf5oDnotSR9W5JeG9BK6duStGi6J6cPlus9un9Ux1Ya8PQEmGLN5LOJLay_XNe1gmXDXh8xbGncBMy62BZiayRktFW7FP5zyS_sarK1</recordid><startdate>20000331</startdate><enddate>20000331</enddate><creator>Yousufuddin, Mohammed</creator><creator>Shamim, Waqar</creator><creator>Chambers, Jonathan S.</creator><creator>Henein, Michael</creator><creator>Amin, Fouad R.</creator><creator>Anker, Stefan D.</creator><creator>Kemp, Michael</creator><creator>Hooper, James</creator><creator>Coats, Andrew J.S.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000331</creationdate><title>Superiority of endothelin-1 over norepinephrine in exercise-induced alterations of the conduit artery tone of the non-exercised arm in patients with chronic heart failure</title><author>Yousufuddin, Mohammed ; Shamim, Waqar ; Chambers, Jonathan S. ; Henein, Michael ; Amin, Fouad R. ; Anker, Stefan D. ; Kemp, Michael ; Hooper, James ; Coats, Andrew J.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-97f3fdff16efbf48140e80d2f05f0dd3f5a1d95eae654af905a02005899158ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Brachial Artery</topic><topic>Cardiology. Vascular system</topic><topic>Chronic heart failure</topic><topic>Endothelin-1</topic><topic>Endothelin-1 - blood</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Heart</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - rehabilitation</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Norepinephrine</topic><topic>Norepinephrine - blood</topic><topic>Regional Blood Flow</topic><topic>Vascular tone</topic><topic>Vasoconstriction</topic><topic>Vasomotor System - metabolism</topic><topic>Vasomotor System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yousufuddin, Mohammed</creatorcontrib><creatorcontrib>Shamim, Waqar</creatorcontrib><creatorcontrib>Chambers, Jonathan S.</creatorcontrib><creatorcontrib>Henein, Michael</creatorcontrib><creatorcontrib>Amin, Fouad R.</creatorcontrib><creatorcontrib>Anker, Stefan D.</creatorcontrib><creatorcontrib>Kemp, Michael</creatorcontrib><creatorcontrib>Hooper, James</creatorcontrib><creatorcontrib>Coats, Andrew J.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yousufuddin, Mohammed</au><au>Shamim, Waqar</au><au>Chambers, Jonathan S.</au><au>Henein, Michael</au><au>Amin, Fouad R.</au><au>Anker, Stefan D.</au><au>Kemp, Michael</au><au>Hooper, James</au><au>Coats, Andrew J.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superiority of endothelin-1 over norepinephrine in exercise-induced alterations of the conduit artery tone of the non-exercised arm in patients with chronic heart failure</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2000-03-31</date><risdate>2000</risdate><volume>73</volume><issue>1</issue><spage>15</spage><epage>25</epage><pages>15-25</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>This study is aimed at examining the relative importance of norepinephrine and endothelin-1 in treadmill exercise-induced changes in brachial arterial tone of the non-exercised arm in patients with chronic heart failure (CHF). Brachial artery diameter and blood flow were measured before and after exercise in eight healthy volunteers and 18 patients with stable chronic heart failure by high-resolution ultrasound. Maximal exercise resulted in brachial artery dilatation in controls (4.42±0.39 vs. 4.77±0.39 mm;
P<0.0001) in contrast to constriction seen in the patients (5.27±0.67 vs. 5.12±0.66 mm;
P=0.07). Both groups demonstrated a significant increase in blood flow after exercise. The pre-exercise (2.83±0.76 vs. 1.69±0.15 pmol/l;
P=0.0004), post-exercise (4.15±1.5 vs. 2.02±0.34 pmol/l;
P=0.0004) and the percent increase (47.15±32.5 vs. 19.0±10.5%;
P=0.02) in endothelin-1 levels were significantly greater in patients than in controls. In contrast to endothelin-1, the exercise-induced percent increase in norepinephrine was greater in controls than patients (100.7±51.8 vs. 49.8±43.4%;
P=0.01). The percent change in the diameter of the brachial artery in response to maximal exercise was significantly correlated to pre- (
r=0.634;
P=0.003) and post-exercise (
r=0.467;
P=0.05) endothelin-1 levels in patients but not in controls [pre-exercise (
r=0.07;
P=0.86), post-exercise (
r=0.310;
P=0.47)]. The change in the diameter of the brachial artery did not correlate with pre- or post-exercise plasma norepinephrine levels in either group. These findings suggest that endothelin-1 is potentially more important than norepinephrine in contributing exercise-induced brachial artery constriction in patients with chronic heart failure.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10748306</pmid><doi>10.1016/S0167-5273(99)00200-4</doi><tpages>11</tpages></addata></record> |
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| ispartof | International journal of cardiology, 2000-03, Vol.73 (1), p.15-25 |
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| subjects | Biological and medical sciences Brachial Artery Cardiology. Vascular system Chronic heart failure Endothelin-1 Endothelin-1 - blood Endothelium, Vascular - metabolism Exercise Exercise - physiology Heart Heart Failure - blood Heart Failure - rehabilitation Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hemodynamics Humans Linear Models Male Medical sciences Middle Aged Norepinephrine Norepinephrine - blood Regional Blood Flow Vascular tone Vasoconstriction Vasomotor System - metabolism Vasomotor System - physiology |
| title | Superiority of endothelin-1 over norepinephrine in exercise-induced alterations of the conduit artery tone of the non-exercised arm in patients with chronic heart failure |
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