The use of alteplase to restore patency of central venous lines in pediatric patients: A cohort study
We evaluated the efficacy and safety of alteplase to restore central venous line (CVL) patency in a consecutive cohort study. A uniform, weight-dependent protocol for alteplase administration was established prospectively. For children ≤10 kg, a dose of 0.5 mg was used; for children >10 kg, doses...
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| Veröffentlicht in: | The Journal of pediatrics 2001-07, Vol.139 (1), p.152-156 |
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| container_title | The Journal of pediatrics |
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| creator | Choi, Matthew Massicotte, M.Patricia Marzinotto, Velma Chan, Anthony K.C. Holmes, Joanne L. Andrew, Maureen |
| description | We evaluated the efficacy and safety of alteplase to restore central venous line (CVL) patency in a consecutive cohort study. A uniform, weight-dependent protocol for alteplase administration was established prospectively. For children ≤10 kg, a dose of 0.5 mg was used; for children >10 kg, doses of 1 to 2 mg were used. The alteplase remained instilled for 1 to 4 hours or overnight. Retrospective data accrual found that 25 children received alteplase for a total of 34 courses; 29 (85%) of the 34 courses of alteplase completely restored CVL patency. Alteplase appears to be a safe and effective thrombolytic agent for CVL patency restoration in children. (J Pediatr 2001;139:152-6) |
| doi_str_mv | 10.1067/mpd.2001.115019 |
| format | Article |
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A uniform, weight-dependent protocol for alteplase administration was established prospectively. For children ≤10 kg, a dose of 0.5 mg was used; for children >10 kg, doses of 1 to 2 mg were used. The alteplase remained instilled for 1 to 4 hours or overnight. Retrospective data accrual found that 25 children received alteplase for a total of 34 courses; 29 (85%) of the 34 courses of alteplase completely restored CVL patency. Alteplase appears to be a safe and effective thrombolytic agent for CVL patency restoration in children. (J Pediatr 2001;139:152-6)</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1067/mpd.2001.115019</identifier><identifier>PMID: 11445811</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. 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A uniform, weight-dependent protocol for alteplase administration was established prospectively. For children ≤10 kg, a dose of 0.5 mg was used; for children >10 kg, doses of 1 to 2 mg were used. The alteplase remained instilled for 1 to 4 hours or overnight. Retrospective data accrual found that 25 children received alteplase for a total of 34 courses; 29 (85%) of the 34 courses of alteplase completely restored CVL patency. Alteplase appears to be a safe and effective thrombolytic agent for CVL patency restoration in children. (J Pediatr 2001;139:152-6)</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Catheterization, Central Venous</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Emergency and intensive care: techniques, logistics</subject><subject>Female</subject><subject>Fibrinolytic Agents - administration & dosage</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Perfusions. Catheterizations. 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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Catheterization, Central Venous Child Cohort Studies Emergency and intensive care: techniques, logistics Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - therapeutic use Humans Intensive care medicine Male Medical sciences Perfusions. Catheterizations. Hyperbaric oxygenotherapy Prospective Studies Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - therapeutic use |
| title | The use of alteplase to restore patency of central venous lines in pediatric patients: A cohort study |
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