Molecular Interactions Between Two Long-QT Syndrome Gene Products, HERG and KCNE2, Rationalized by In Vitro and In Silico Analysis

ABSTRACT—The cardiac delayed rectifier potassium current mediates repolarization of the action potential and underlies the QT interval of the ECG. Mutations in either of the two molecular components of the rapid delayed rectifier (IK,r), HERG and KCNE2, have been linked to heritable or acquired long...

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Veröffentlicht in:	Circulation research 2001-07, Vol.89 (1), p.33-38
Hauptverfasser:	Mazhari, Reza, Greenstein, Joseph L, Winslow, Raimond L, Marbán, Eduardo, Nuss, H Bradley
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Biological and medical sciences Cardiac dysrhythmias Cardiology. Vascular system Cation Transport Proteins Cell Line Delayed Rectifier Potassium Channels DNA-Binding Proteins Electric Conductivity ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels Heart Humans Ion Channel Gating Kinetics Long QT Syndrome - etiology Markov Chains Medical sciences Models, Theoretical Potassium Channels - physiology Potassium Channels, Voltage-Gated Trans-Activators Transcriptional Regulator ERG
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