DNA constraints on transcription activation in Vitro

Activators of eukaryotic transcription often function over a range of distances. It is commonly hypothesized that the intervening DNA between the transcription start site and the activator binding sites forms a loop in order to allow the activators to interact with the basal transcription apparatus,...

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Veröffentlicht in:	Journal of molecular biology 2000-03, Vol.297 (2), p.321-334
Hauptverfasser:	Ross, Eric D, Keating, Anne M, Maher, L.James
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Adenovirus Adenovirus E4 Proteins - genetics Binding Sites DNA - chemistry DNA - genetics DNA - metabolism DNA bending DNA curvature DNA, Superhelical - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E4 protein Fungal Proteins - genetics Fungal Proteins - metabolism Gal4 protein HeLa Cells Humans Models, Genetic Nucleic Acid Conformation phasing Promoter Regions, Genetic - genetics Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Response Elements - genetics Saccharomyces cerevisiae Proteins Tandem Repeat Sequences - genetics TATA Box - genetics Templates, Genetic Thermodynamics Trans-Activators - genetics Trans-Activators - metabolism transcription Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - genetics Transcriptional Activation - genetics
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