Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits

To evaluate the effects of topically applied anandamide transport inhibitors, AM404 and olvanil, on the intraocular pressure (IOP) of normotensive rabbits. To determine if the ocular hypotension induced by topical anandamide (AEA) can be potentiated by co-administered AM404. Test compounds, in eithe...

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Veröffentlicht in:	Pharmaceutical research 2001-04, Vol.18 (4), p.494-499
Hauptverfasser:	LAINE, Krista, JÄRVINEN, Tomi, SAVINAINEN, Juha, LAITINEN, Jarmo T, PATE, David W, JÄRVINEN, Kristiina
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Arachidonic Acids - antagonists & inhibitors Arachidonic Acids - chemistry Arachidonic Acids - pharmacology Biological and medical sciences Biological Transport - drug effects Biological Transport - physiology Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacology Capsaicin - analogs & derivatives Capsaicin - chemistry Capsaicin - pharmacology Endocannabinoids Eye Female General pharmacology Intraocular Pressure - drug effects Intraocular Pressure - physiology Male Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyunsaturated Alkamides Rabbits Rats Rats, Wistar
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